Alpha-keto-boswellic acid

Bio-Activity Analysis
Inflammatory Enzyme Inhibition (5-LOX)
SCIENTIFIC DATA VISUALIZATION
Health Benefits & Sources
Why You Need It
- Joint Comfort: It significantly reduces pain and stiffness in arthritic joints.
- Inflammation Control: It blocks specific enzymes that trigger swelling in the body.
- Gut Health: It helps heal the intestinal lining, aiding those with IBD or leaky gut.
- Breathing Support: It opens up airways, making it easier to breathe for asthma sufferers.
Deep Dive
Alpha-keto-boswellic acid (AKBA) is the most potent active ingredient found in Boswellia serrata resin. Its primary superpower is inhibiting an enzyme called 5-lipoxygenase (5-LOX). In simple terms, 5-LOX creates inflammatory molecules in your body called leukotrienes. By stopping this enzyme, AKBA effectively turns down the volume on inflammation. This is crucial because chronic inflammation is the root cause of many modern diseases, including osteoarthritis. Research shows that AKBA can protect cartilage from breaking down, keeping your joints cushioned and moving smoothly.
Natural Food Sources
Unlike Vitamin C found in oranges, Alpha-keto-boswellic acid is not found in standard fruits or vegetables. It is exclusively sourced from the resin (gum) of the Boswellia serrata tree, native to India, Africa, and the Middle East. Traditionally, the resin is chewed or made into incense. To get the therapeutic dose used in studies, you generally need an extract rather than just food.
Supplementation
Because the raw resin is tough to consume, most people take it as a standardized extract (often labeled as 65% Boswellic Acids or specifically AKBA).
- Dosage: Clinical studies often use 300mg to 500mg, taken 2 to 3 times daily.
- Absorption Tip: Look for supplements labeled with "Acetyl-11-keto-beta-boswellic acid" (AKBA) or those using trademarked absorption technologies (like Casperome®), as pure Boswellia resin can be hard for the body to absorb.
Top Food Sources
Frequently Asked Questions
Safety & Side Effects
Safety & Side Effects
Alpha-keto-boswellic acid is generally considered very safe and well-tolerated by most people.
- Side Effects: Rare and mild. Some may experience slight stomach upset, nausea, or skin rash.
- Interactions: Because it has mild blood-thinning properties, use caution if you are taking anticoagulants (like Warfarin/Coumadin) or aspirin.
- Who Should Avoid: Pregnant women should avoid high doses due to its potential ability to stimulate blood flow in the uterus. Always consult your doctor before starting a new supplement regimen.
Scientific References
- [1]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560136/ (Efficacy and safety of Boswellia serrata extract in osteoarthritis)
- [2]https://pubmed.ncbi.nlm.nih.gov/24436107/ (AKBA inhibits 5-LOX enzyme activity)
- [3]https://www.sciencedirect.com/science/article/pii/S0944711317302031 (Boswellia in inflammatory bowel disease)