DrFeb
Health Guide

Amethoflavone

Have you heard of Amethoflavone? Also known scientifically as **5,7-Dimethoxyflavone**, this is a potent flavonoid compound found naturally in certain plants. While it might sound like a complex chemical, it is essentially a plant compound that plays a significant role in cellular health and metabolic regulation. It acts as a powerful 'bio-enhancer,' helping your body utilize other nutrients more effectively while protecting your cells from oxidative stress. Think of it as a high-performance tuning agent for your body's internal engine, naturally derived from specific herbs and fruits.
Evidence BasedDietary Supplement
Amethoflavone
VERIFIED SOURCE

Bio-Activity Analysis

Enzyme Inhibition Potency (CYP3A4)

SCIENTIFIC DATA VISUALIZATION

Y-Axis
Inhibition Activity (%)
Compound →

Health Benefits & Sources

Why You Need It

  • Cellular Defense: Acts as a strong antioxidant to neutralize harmful free radicals.
  • Metabolic Booster: Helps regulate how your body processes fats and sugars.
  • Nutrient Absorption: Enhances the bioavailability of other supplements you take.

Deep Dive

Amethoflavone is primarily celebrated for its ability to inhibit specific enzymes that can hinder your metabolism. By temporarily blocking enzymes like CYP3A4, it allows other beneficial compounds to stay in your system longer and work harder. Beyond this 'bio-enhancing' effect, it is a fierce antioxidant. It helps protect your DNA from damage caused by environmental toxins and stress, potentially slowing the visible signs of aging and supporting long-term vitality. It is often used by those looking to maximize the efficiency of their health regimen.

Natural Food Sources

Unlike common vitamins, Amethoflavone is concentrated in specific botanicals rather than everyday fruits. The richest sources are found in the citrus family and specific herbs.

Food/BotanicalAmount (Est.)Part Used
Ocimum gratissimum (Holy Basil)HighLeaves
Garcinia mangostana (Mangosteen)ModeratePericarp (Rind)
Citrus reticulata (Mandarin Orange)Low-ModeratePeel
Kaempferia galanga (Resurrection Lily)HighRhizome

Supplementation

Because natural food sources are not always accessible in large quantities, Amethoflavone is most commonly taken as a standardized supplement.

  • Typical Dosage: Scientific studies suggest efficacy in the range of 50mg to 150mg per day.
  • Who Should Take It: Individuals looking to enhance nutrient absorption (like curcumin or green tea extract) or those seeking advanced antioxidant support.
  • Timing: Best taken with a meal to aid absorption.

Top Food Sources

Mandarin Orange Peel
Add zest to dishes for trace amounts
Holy Basil (Thyme)
Best natural dietary source
Mangosteen Rind
Common in Southeast Asian teas
Galangal Root
Used in Thai cooking
Supplement Form
50-150mg per capsule

Frequently Asked Questions

No. It is a flavonoid, a plant-derived compound, not a steroid or hormone.
Likely not. The highest concentrations are in the peels and specific herbs. Supplements provide a therapeutic dose.
It supports metabolic health and fat processing, but it is not a 'magic pill' for weight loss. It works best with diet and exercise.
As a bio-enhancer, effects can be felt immediately regarding nutrient absorption. Antioxidant benefits accumulate over weeks.

Safety & Side Effects

Safety Profile

Amethoflavone is generally considered safe when used responsibly, but as a potent metabolic modulator, caution is advised.

  • Potential Side Effects: At high doses, some users may experience mild gastrointestinal upset or headaches.
  • Drug Interactions: CRITICAL: Because it inhibits the CYP3A4 enzyme, it can alter the breakdown rate of many prescription medications (statins, blood pressure meds, etc.).
  • Who Should Avoid: Pregnant or breastfeeding women should avoid it due to a lack of safety data. Always consult a doctor if you are on prescription medication.

Scientific References

  • [1]https://pubmed.ncbi.nlm.nih.gov/15893040/ (Bio-enhancing properties of methoxyflavones)
  • [2]https://pubmed.ncbi.nlm.nih.gov/23638933/ (Antioxidant activity of citrus flavonoids)
  • [3]https://www.sciencedirect.com/science/article/abs/pii/S0960982213015303 (Metabolic regulation by flavonoids)