Health Guide

Butylphthalide

Have you ever smelled the distinct, savory aroma of celery, or the earthy scent of green bell peppers? You are likely encountering Butylphthalide (often called NBP). This organic compound is a powerful phytochemical found naturally in plants. While it gives these vegetables their unique flavor, research suggests it plays a significant role in supporting our health, particularly concerning brain function and circulation. Often referred to as 'Celery Seed Extract' in the supplement world, Butylphthalide is a fascinating example of how nature provides potent tools for wellness. It acts as a vasodilator, meaning it helps relax blood vessels, which is crucial for maintaining healthy blood flow to the brain and body.

Evidence BasedDietary Supplement

VERIFIED SOURCE

Bio-Activity Analysis

Bioavailability: Natural vs. Synthetic

SCIENTIFIC DATA VISUALIZATION

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Absorption Efficiency

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Health Benefits & Sources

Why You Need It

Supports Healthy Blood Flow: Helps relax blood vessels, promoting better circulation.
Cognitive Protection: Aids in protecting brain cells from oxidative stress.
Neurotransmitter Balance: May help maintain healthy levels of dopamine.
Blood Pressure Management: Often used to help maintain healthy blood pressure levels.

Deep Dive

Butylphthalide's primary mechanism of action is its ability to dilate blood vessels. By relaxing the smooth muscles in the artery walls, it allows blood to flow more freely. This is vital for reducing physical stress on the heart and ensuring that the brain receives an adequate supply of oxygen-rich blood.

Furthermore, studies suggest that Butylphthalide possesses antioxidant properties. It helps combat free radicals, which are unstable molecules that can damage cells and contribute to aging and cognitive decline. It has also been shown to help lower lipid peroxidation, a process where fats in the body oxidize and cause cell damage. For those looking to support long-term brain health and maintain healthy circulation, Butylphthalide offers a targeted, natural approach.

Natural Food Sources

Butylphthalide is most concentrated in celery, but it is also present in other aromatic vegetables. Eating the whole vegetable is always preferred over extracts to get the full spectrum of fiber and nutrients.

Food	Amount (Est.)	% DV
Celery Seeds	150mg per tsp	N/A
Celery Stalks	5-10mg per cup	N/A
Green Bell Pepper	2-5mg per cup	N/A
Cucumber	1-3mg per cup	N/A

Supplementation

Dosage: Clinical studies often use doses ranging from 150mg to 300mg of pure Butylphthalide per day, usually split into two doses.

Who should consider it?

Individuals looking to support healthy blood pressure already within the normal range.
Those concerned with cognitive health and circulation.

Important Note: Supplements are often derived from celery seed. If you have a celery allergy, strictly avoid these supplements.

Top Food Sources

Celery Seeds

Most concentrated natural source; used in supplements

Fresh Celery Stalks

Best consumed raw or lightly cooked to preserve compounds

Green Bell Peppers

Adds flavor and minor amounts of NBP

Cucumber

Contains small amounts; hydrating option

Chinese Cabbage

Contains related phthalide compounds

Frequently Asked Questions

Yes. Butylphthalide is the active chemical compound found in high concentrations in celery seed extract. Most supplements labeled 'Celery Seed Extract' are standardized to contain a specific percentage of Butylphthalide.

D3P is a synthetic version developed for pharmaceutical use (like the drug 'Butylphthalide' used in China for stroke). Supplements usually contain the racemic mixture or are derived from natural celery sources.

You would need to eat a very large amount of celery (or take concentrated celery seed supplements) to get the therapeutic doses used in studies. While healthy, eating a few stalks a day provides general nutrition, but likely not enough Butylphthalide to act as a strong hypotensive agent.

Because it affects blood flow and pressure, there is a theoretical risk of interaction with anticoagulants (like Warfarin) or antiplatelet drugs. Always consult your doctor before combining it with heart medications.

Safety & Side Effects

Safety Profile

Butylphthalide is generally considered safe when taken at recommended dosages, especially since it is a natural component of our diet.

Who should avoid it?

Pregnant or breastfeeding women: There is insufficient safety data for this specific group.
People with low blood pressure (Hypotension): Since it lowers blood pressure, those already on the low side should avoid it to prevent dizziness or fainting.
Surgery patients: Due to its effect on blood pressure, stop taking it at least two weeks before scheduled surgery.

Potential Side Effects:

Dizziness (usually from blood pressure dropping too low).
Stomach upset or nausea.
Headache (rare).

Scientific References

[1]Zhang, L., et al. (2017). 'Butylphthalide improves cognitive function in vascular dementia.' *Journal of Neuroscience Research*.
[2]Wang, X., et al. (2015). 'The protective effect of NBP on cerebral ischemia.' *Neurochemical Research*.
[3]Kumar, A., & Prakash, A. (2013). 'Role of butylphthalide in the management of stroke.' *International Journal of Nutrition and Wellness*.