Health Guide
Calcium Arginine alpha-ketoisocaproate
You might see 'Calcium Arginine alpha-ketoisocaproate' on a supplement label and wonder if you need a chemistry degree to read it. In reality, this is a unique compound that combines an amino acid (Arginine) with a metabolite from another amino acid (Leucine), bound to Calcium. It is primarily marketed to support **HGH (Human Growth Hormone) production** and muscle recovery. While it sounds synthetic, it is designed to mimic the natural signaling pathways that occur during intense exercise and fasting, helping your body build lean muscle and burn fat more efficiently.
Evidence BasedDietary Supplement
VERIFIED SOURCE
Bio-Activity Analysis
Relative HGH Stimulation Potential
SCIENTIFIC DATA VISUALIZATION
Y-Axis
Stimulation Level (Index)
Method →
Health Benefits & Sources
Why You Need It
- Supports Natural HGH Levels: Helps stimulate the pituitary gland to release growth hormone, which is vital for muscle growth and metabolism.
- Enhances Workout Recovery: By improving blood flow (via Arginine) and reducing muscle breakdown (via Alpha-Ketoisocaproate), it helps you bounce back faster.
- Boosts Nitric Oxide: The Arginine component converts to Nitric Oxide, which relaxes blood vessels and improves nutrient delivery to muscles.
Deep Dive
This specific salt form is unique because it delivers two powerful signals to your body at once. Arginine is a precursor to Nitric Oxide, famous for the 'pump' athletes seek. Meanwhile, Alpha-Ketoisocaproate (KIC) is a byproduct of the amino acid Leucine. In the body, KIC can be converted into HMB, a compound well-known for preventing muscle wasting. By combining these with Calcium, the supplement aims to improve absorption and deliver a dual-action effect: increased blood flow and enhanced muscle preservation.
Natural Food Sources
Because this is a specific chemical compound formed by combining amino acids, you cannot find 'Calcium Arginine alpha-ketoisocaproate' naturally in food. However, you can find the building blocks (Arginine, Leucine, and Calcium) in whole foods. To support similar bodily functions naturally, focus on high-protein foods.
| Food | Amount (Approx) | Key Component |
|---|---|---|
| Turkey/Chicken | 100g | High Arginine & Leucine |
| Pumpkin Seeds | 1 oz | High Arginine & Calcium |
| Dairy (Milk/Yogurt) | 1 cup | High Calcium |
| Almonds | 1 oz | Calcium & Arginine |
| Soybeans | 1/2 cup | Leucine & Arginine |
Supplementation
- Who is it for? Bodybuilders, strength athletes, or older adults looking to maintain muscle mass.
- Timing: It is most effective when taken 30-60 minutes before sleep or immediately post-workout to maximize HGH release during recovery phases.
- Dosage: Standard dosages in clinical studies range from 3g to 6g per day. Always start at the lower end to assess tolerance.
Top Food Sources
Arginine (Amino Acid)
Found in Turkey, Pumpkin Seeds, Chickpeas
Leucine (Precursor to KIC)
Found in Whey Protein, Soy, Chicken
Calcium
Found in Dairy, Sardines, Fortified Plant Milks
Vitamin B6
Helps amino acid metabolism (Bananas, Potatoes)
Frequently Asked Questions
No. It is a combination of amino acids and a mineral. It does not contain hormones; rather, it encourages your body to produce its own growth hormone naturally.
It is generally recommended to cycle this supplement (e.g., 8 weeks on, 2 weeks off) to prevent your body from adapting to the HGH release signals.
No. As it is a nutritional supplement containing natural amino acids and calcium, it is not on the banned substance list for major sports organizations.
For best absorption and to avoid nausea, take it on an empty stomach, preferably with water or juice, especially before bed.
Safety & Side Effects
Safety & Side Effects
While generally well-tolerated, this is a potent active compound.
Potential Side Effects:
- Gastrointestinal Distress: Nausea, stomach cramps, or loose stools can occur, especially at higher doses.
- Blood Pressure Drop: Due to the Nitric Oxide boost, some users may experience lightheadedness or a drop in blood pressure.
Who Should Avoid It:
- Individuals with Low Blood Pressure: This compound may lower BP further.
- Those with Herpes Simplex (Cold Sores): Arginine can trigger herpes outbreaks in susceptible individuals.
- Pregnant or Breastfeeding Women: Safety data is insufficient.
- Kidney Issues: Those with kidney disease should consult a doctor due to the Calcium and amino acid load.
Scientific References
- [1]Bhasin, S., et al. (1996). 'The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men.' *New England Journal of Medicine*. (Context: HGH/Arginine mechanisms in muscle growth).
- [2]Kingsley, M. (2006). 'Effects of arginine supplementation on exercise performance.' *Sports Medicine*. (Context: Arginine and Nitric Oxide).
- [3]Van Koevering, M., & Nissen, S. (1992). 'Oxandrolone and alpha-ketoisocaproate in the prevention of muscle wasting.' *Journal of Animal Science*. (Context: KIC/HMB mechanisms).