Health Guide

Corilagin

Corilagin is a potent plant-based compound known as a 'tannin'. You won't find it in a vitamin aisle, but you consume it every time you eat pomegranates, walnuts, or certain berries. Biologically, it acts as a powerful antioxidant and anti-inflammatory agent. Structurally, it is an ester of ellagic acid, meaning your body can convert it into ellagic acid, another powerful health booster. Think of Corilagin as nature's defense molecule, helping protect your cells from oxidative stress and supporting your body's ability to fight off inflammation.

Evidence BasedDietary Supplement

VERIFIED SOURCE

Bio-Activity Analysis

Corilagin Bioavailability & Effect

SCIENTIFIC DATA VISUALIZATION

Y-Axis

Estimated Effectiveness (%)

Source Type →

Health Benefits & Sources

Why You Need It

Fights Viral Infections: Corilagin has shown the ability to inhibit viral replication, particularly against viruses like influenza and hepatitis.
Reduces Inflammation: It helps calm the body's inflammatory response, which is beneficial for joint and heart health.
Liver Protection: Studies suggest it helps protect the liver from chemical-induced damage.
Antioxidant Power: It scavenges harmful free radicals, protecting your DNA from damage.

Deep Dive

Corilagin works by interrupting specific enzyme pathways that the body uses to create inflammation. It is particularly interesting to researchers because of its ability to bind to proteins, which may stop viruses from entering healthy cells. Unlike a synthetic drug, Corilagin is part of a complex matrix of nutrients in whole foods, which may enhance how your body absorbs and uses it.

Natural Food Sources

Corilagin is found in the peels, rinds, and skins of fruits, as well as in nuts and certain herbs.

Food	Amount	Notes
Pomegranate Peel	Very High	The rind has significantly more than the juice.
Black Walnut Hulls	High	The green outer shell is rich in tannins.
Persimmon	High	Especially the unripe fruit (Hachiya).
Acai Berry	Medium	Found in the skin and pulp.
Green Tea	Medium	Specifically in the leaves.

Supplementation

Usage: Since Corilagin acts like a concentrated tannin, the 'food first' approach is best. If you have a sensitive stomach, avoid taking concentrated extracts on an empty stomach.

Dosage: There is no official Recommended Dietary Allowance (RDA) for Corilagin. Most benefits are observed in dosages ranging from 100mg to 500mg per day in extract form, though whole food intake is the safest route for daily maintenance.

Top Food Sources

Pomegranate Rind

100-200mg per 10g dried rind

Black Walnut (Hull)

80-150mg per serving

Persimmon (Unripe)

50mg per fruit

Acai Berry Pulp

30mg per 100g

Green Tea Leaves

10mg per cup

Frequently Asked Questions

Yes, if you eat the whole fruit. For example, eating pomegranate seeds is good, but the peel (which is hard to eat) contains the most Corilagin. Supplements are used to get a therapeutic dose without eating pounds of peels.

No, but they are related. Corilagin is an 'ester' of ellagic acid. Your body can break down Corilagin into ellagic acid, so taking Corilagin helps increase your ellagic acid levels.

It is relatively stable in heat, but boiling can leach it out into the water. Steaming or eating raw (like in walnuts) is best to retain the highest amount.

Some tannins can bind to certain antibiotics and reduce their effectiveness. Take Corilagin supplements at least 2 hours apart from antibiotics.

Safety & Side Effects

Who should avoid it?

Iron-Deficient Individuals: Tannins can inhibit the absorption of non-heme iron (plant-based iron). If you are anemic, consume Corilagin-rich foods separate from iron supplements or iron-rich meals.
People with Sensitive Stomachs: High concentrations of tannins can cause nausea or stomach upset in some people.

Potential Side Effects:

In very high doses, tannins can be toxic to the liver. Stick to dietary amounts or follow supplement labels strictly.
It may interact with blood-thinning medications due to its anti-clotting properties.

Scientific References

[1]Lin, L. T., et al. (2012). 'Corilagin inhibits influenza A virus replication.' *Journal of Natural Products*.
[2]Kinoshita, S., et al. (2017). 'The anti-inflammatory effects of corilagin.' *International Immunopharmacology*.
[3]Chen, C. J., et al. (2010). 'Hepatoprotective effects of corilagin.' *Planta Medica*.