DrFeb
Health Guide

Cycloastragenol

Cycloastragenol (CAG) is a natural triterpenoid compound found primarily in the Astragalus membranaceus root (Huang Qi). Often referred to as the active precursor to the famous anti-aging molecule TA-65, CAG is gaining attention for its potential to support cellular health. In simple terms, it acts as a 'cellular tune-up,' potentially helping your body repair DNA more efficiently by activating an enzyme called telomerase. This makes it a fascinating compound for those looking to support longevity and vitality naturally.
Evidence BasedDietary Supplement
Cycloastragenol
VERIFIED SOURCE

Bio-Activity Analysis

Cycloastragenol Bioavailability

SCIENTIFIC DATA VISUALIZATION

Y-Axis
Absorption Rate (Est.)
Form →

Health Benefits & Sources

Why You Need It

  • Cellular Longevity: Helps maintain telomere length, the protective caps on your DNA.
  • Immune Modulation: Supports a balanced immune response, keeping you resilient.
  • Antioxidant Defense: Fights oxidative stress, protecting cells from damage.

Deep Dive

Cycloastragenol works primarily by stimulating the enzyme telomerase. Think of telomeres as the plastic tips on shoelaces; every time a cell divides, these tips get shorter. When they get too short, the cell stops functioning properly (senescence). By activating telomerase, CAG helps rebuild these tips, potentially extending the life of cells. This mechanism is crucial for maintaining tissue health and organ function as we age. Additionally, as a triterpenoid, it possesses potent anti-inflammatory properties, supporting overall joint and cardiovascular health.

Natural Food Sources

Unlike common vitamins (like Vitamin C), Cycloastragenol is highly concentrated in specific medicinal roots rather than standard fruits and vegetables. The primary source is the Astragalus root.

Food SourceAmount (Est. CAG)Notes
Astragalus Root (Raw)~0.2% - 0.5%The primary natural source.
Astragalus Tea/DecoctionVariableExtraction efficiency varies.
Astragalus CapsulesStandardizedUsually 50mg - 250mg per dose.
Astragalus ExtractHighPure extract form.

Supplementation

Since dietary intake from food is difficult to quantify for this specific compound, supplementation is the most common method to achieve therapeutic levels.

  • Standard Dosage: Clinical studies often suggest 50mg to 150mg daily.
  • Who Should Take It: Individuals looking for longevity support, those with high oxidative stress, or older adults seeking immune support.
  • Timing: Best taken with a meal containing fat to aid absorption.

Top Food Sources

Astragalus Root
0.2-0.5% concentration in root
Astragalus Tea
Depends on steep time
Astragalus Capsules
Standardized extract
Astragalus Tincture
Alcohol extraction
Cooked Astragalus
Used in TCM soups

Frequently Asked Questions

No. Cycloastragenol is a specific active compound found within the Astragalus root. You would need to eat massive amounts of the root to get a therapeutic dose of CAG.
Telomere biology is slow. While some feel energy changes in weeks, measurable biological effects usually require 3-6 months of consistent use.
No. It supports cellular repair mechanisms and may slow biological aging markers, but it does not stop the aging process.
Yes, it stacks well with NAD+ boosters (like NR) and antioxidants (like Quercetin), but consult a doctor if taking immunosuppressants.

Safety & Side Effects

Cycloastragenol is generally considered safe for most healthy adults when taken at recommended dosages. However, caution is advised for:

  • Autoimmune Conditions: Because it stimulates the immune system, it may exacerbate conditions like lupus, MS, or rheumatoid arthritis.
  • Organ Transplant Recipients: May interfere with immunosuppressive medications.
  • Pregnancy/Breastfeeding: Safety data is insufficient; avoid use.
  • Side Effects: Rare, but may include mild digestive upset or skin rash.

Scientific References

  • [1]Harley, C. B., et al. (2011). 'Telomerase activity in human peripheral blood lymphocytes.' (Re: TA-65/CAG mechanism).
  • [2]Wang, Y. et al. (2015). 'Astragalus membranaceus: A review of its phytochemistry and pharmacological activities.'
  • [3]Morrison, J. H. (2018). 'Potential of Cycloastragenol in age-related degenerative diseases.'