Health Guide

Decursin

Decursin is a potent bioactive compound found primarily in the root of *Angelica gigas* (also known as Korean Angelica), a herb widely used in traditional Korean medicine. Classified as a pyranocoumarin, Decursin has captured the attention of modern researchers for its powerful anti-inflammatory, neuroprotective, and potential anti-cancer properties. While it is not a 'vitamin' or 'mineral' your body produces, it acts as a powerful adaptogen, helping your body manage stress and cellular damage. Think of it as a specialized shield for your cells, helping to maintain balance and function as you age.
Evidence BasedDietary Supplement
Decursin
VERIFIED SOURCE

Bio-Activity Analysis

Potency Comparison: Angelica Gigas Extracts

SCIENTIFIC DATA VISUALIZATION

Y-Axis
Bioactivity Score (Relative)
Compound

Health Benefits & Sources

Why You Need It

  • Cognitive Protection: Decursin acts as a neuroprotective agent, potentially shielding brain cells from oxidative stress.
  • Anti-Inflammatory Power: It mimics the effects of steroids in the body, helping to reduce swelling and pain naturally.
  • Cellular Integrity: Early research suggests it helps induce apoptosis (programmed cell death) in damaged or abnormal cells.

Deep Dive

Decursin is the star player in Angelica gigas. Its primary mechanism of action involves inhibiting NF-kB, a protein complex that acts as a switch for inflammation in the body. By turning down this switch, Decursin helps reduce chronic inflammation, which is often the root cause of many age-related diseases.

For the brain, it has been shown to protect neurons from toxins and may improve memory retention in animal studies. While human trials are ongoing, the evidence points toward Decursin as a powerful ally for maintaining long-term cognitive health and vitality.

Natural Food Sources

Unlike common vitamins, Decursin is highly specialized. It is not found in standard fruits or vegetables. It is exclusively isolated from the roots of the Angelica family of plants.

Food SourcePart UsedEst. Decursin Content
Angelica gigasDried RootHigh (Extracts used for supplements)
Angelica sinensis (Dang Gui)RootTrace amounts
Angelica archangelicaRoot/SeedsTrace amounts

Supplementation

Dosage:

  • Standard Extract: 50mg to 200mg daily.
  • Standardization: Look for extracts standardized to contain 2-3% Decursin to ensure potency.

Who should take it?

  • Individuals looking for natural cognitive support.
  • Those managing inflammatory discomfort (joint health).
  • Note: Always consult a doctor before starting a new herbal supplement.

How to take it: Usually found in capsule form. Because it is fat-soluble, taking it with a meal containing healthy fats (like avocado or olive oil) may improve absorption.

Top Food Sources

Angelica Gigas Root
Only source of therapeutic levels
Angelica Sinensis (Dang Gui)
Contains related compounds
Angelica Archangelica
Contains related compounds
Standard Diet
Not found in fruits or veggies

Frequently Asked Questions

Yes. It is a natural compound found in the roots of the Korean Angelica plant (*Angelica gigas*).
It has sedative properties. It is best taken in the evening or when you do not need to be alert.
No. The concentration of Decursin in raw root is low. Supplements use concentrated extracts to achieve therapeutic benefits.
For inflammation, some users report relief in 1-2 weeks. For cognitive support, it may take 4-6 weeks of consistent use.

Safety & Side Effects

Safety & Side Effects

Safety Profile: Decursin is generally considered safe at standard supplemental doses, but because it is a potent bioactive compound, it must be respected.

Potential Side Effects:

  • Sedation: It may cause drowsiness. Do not operate heavy machinery until you know how it affects you.
  • Gastrointestinal upset: Mild nausea or stomach cramping can occur.

Who Should Avoid It:

  • Pregnant or Breastfeeding Women: There is insufficient safety data. Avoid use.
  • Bleeding Disorders: Decursin may slow blood clotting. Stop use 2 weeks before any surgery.
  • Hormone-Sensitive Conditions: Because it interacts with hormone receptors, those with breast or uterine cancer should consult an oncologist first.

Drug Interactions:

  • Sedatives: Do not mix with sleep aids or anti-anxiety meds (benzodiazepines).
  • Blood Thinners: Potential interaction with Warfarin.

Scientific References

  • [1]Kwon, O. E., et al. (2005). 'Decursin inhibits growth and induces apoptosis in human glioma cells.' *Journal of Ethnopharmacology*.
  • [2]Kim, J. H., et al. (2019). 'Neuroprotective effects of Decursin against oxidative stress.' *Phytotherapy Research*.
  • [3]Yoo, J. H., et al. (2021). 'Anti-inflammatory mechanisms of Decursinol angelate in macrophages.' *International Immunopharmacology*.