Decursin

Bio-Activity Analysis
Potency Comparison: Angelica Gigas Extracts
SCIENTIFIC DATA VISUALIZATION
Health Benefits & Sources
Why You Need It
- Cognitive Protection: Decursin acts as a neuroprotective agent, potentially shielding brain cells from oxidative stress.
- Anti-Inflammatory Power: It mimics the effects of steroids in the body, helping to reduce swelling and pain naturally.
- Cellular Integrity: Early research suggests it helps induce apoptosis (programmed cell death) in damaged or abnormal cells.
Deep Dive
Decursin is the star player in Angelica gigas. Its primary mechanism of action involves inhibiting NF-kB, a protein complex that acts as a switch for inflammation in the body. By turning down this switch, Decursin helps reduce chronic inflammation, which is often the root cause of many age-related diseases.
For the brain, it has been shown to protect neurons from toxins and may improve memory retention in animal studies. While human trials are ongoing, the evidence points toward Decursin as a powerful ally for maintaining long-term cognitive health and vitality.
Natural Food Sources
Unlike common vitamins, Decursin is highly specialized. It is not found in standard fruits or vegetables. It is exclusively isolated from the roots of the Angelica family of plants.
| Food Source | Part Used | Est. Decursin Content |
|---|---|---|
| Angelica gigas | Dried Root | High (Extracts used for supplements) |
| Angelica sinensis (Dang Gui) | Root | Trace amounts |
| Angelica archangelica | Root/Seeds | Trace amounts |
Supplementation
Dosage:
- Standard Extract: 50mg to 200mg daily.
- Standardization: Look for extracts standardized to contain 2-3% Decursin to ensure potency.
Who should take it?
- Individuals looking for natural cognitive support.
- Those managing inflammatory discomfort (joint health).
- Note: Always consult a doctor before starting a new herbal supplement.
How to take it: Usually found in capsule form. Because it is fat-soluble, taking it with a meal containing healthy fats (like avocado or olive oil) may improve absorption.
Top Food Sources
Frequently Asked Questions
Safety & Side Effects
Safety & Side Effects
Safety Profile: Decursin is generally considered safe at standard supplemental doses, but because it is a potent bioactive compound, it must be respected.
Potential Side Effects:
- Sedation: It may cause drowsiness. Do not operate heavy machinery until you know how it affects you.
- Gastrointestinal upset: Mild nausea or stomach cramping can occur.
Who Should Avoid It:
- Pregnant or Breastfeeding Women: There is insufficient safety data. Avoid use.
- Bleeding Disorders: Decursin may slow blood clotting. Stop use 2 weeks before any surgery.
- Hormone-Sensitive Conditions: Because it interacts with hormone receptors, those with breast or uterine cancer should consult an oncologist first.
Drug Interactions:
- Sedatives: Do not mix with sleep aids or anti-anxiety meds (benzodiazepines).
- Blood Thinners: Potential interaction with Warfarin.
Scientific References
- [1]Kwon, O. E., et al. (2005). 'Decursin inhibits growth and induces apoptosis in human glioma cells.' *Journal of Ethnopharmacology*.
- [2]Kim, J. H., et al. (2019). 'Neuroprotective effects of Decursin against oxidative stress.' *Phytotherapy Research*.
- [3]Yoo, J. H., et al. (2021). 'Anti-inflammatory mechanisms of Decursinol angelate in macrophages.' *International Immunopharmacology*.