Decursinol

Bio-Activity Analysis
Mechanism of Action: Acetylcholinesterase (AChE) Inhibition
SCIENTIFIC DATA VISUALIZATION
Health Benefits & Sources
Why You Need It
- Brain Health Guardian: Protects brain cells from damage and may improve memory.
- Inflammation Fighter: Helps calm the body's inflammatory response naturally.
- Mood & Stress Support: May help regulate stress hormones and support a balanced mood.
Deep Dive
Decursinol works primarily by inhibiting an enzyme called acetylcholinesterase (AChE). In simple terms, high levels of AChE break down acetylcholine, a crucial neurotransmitter for memory and learning. By keeping AChE in check, Decursinol helps maintain healthy acetylcholine levels, supporting sharper focus and cognitive clarity. Furthermore, its strong antioxidant profile helps neutralize harmful free radicals, which are unstable molecules that contribute to aging and cellular damage. This dual action makes it a unique ally for long-term brain vitality and managing everyday inflammation.
Natural Food Sources
Decursinol is not found in common fruits or vegetables. It is a specialized compound concentrated in the roots of specific plants, primarily used in herbal medicine.
| Plant Source | Part Used | Common Use |
|---|---|---|
| Angelica gigas (Danggui) | Dried Root | Teas, Powders, Capsules |
| Angelica archangelica | Root & Seeds | Culinary, Teas |
Supplementation
Because Decursinol is highly concentrated in Angelica roots, therapeutic doses are best achieved through high-quality supplements.
- Typical Dosage: Clinical studies often use extracts standardized to contain 3-5% Decursinol. A common range is 100-300mg of the active compound per day. Always start with the lowest dose to assess tolerance.
- Who Should Take It: Individuals looking for natural cognitive support, those managing mild inflammation, or anyone interested in neuroprotective aging strategies (always consult a doctor first).
Top Food Sources
Frequently Asked Questions
Safety & Side Effects
Decursinol appears to be well-tolerated in moderate doses. However, because it can influence blood flow and enzyme activity, caution is advised. Do not use if you are pregnant or breastfeeding. Individuals with bleeding disorders or those taking blood-thinning medications (like Warfarin) or sedatives should avoid it or consult a healthcare professional, as it may increase the risk of bleeding or enhance sedative effects.
Scientific References
- [1]Kim, H. et al. (2019). 'Decursinol Angelate: A Potential Therapeutic Agent for Cognitive Disorders.' *Journal of Ethnopharmacology*.
- [2]Kang, S. Y. et al. (2005). 'Decursinol from Angelica gigas mitigates amyloid beta-induced cognitive impairment.' *Neuroscience Letters*.
- [3]Zhang, L. et al. (2018). 'Anti-inflammatory effects of Decursinol in macrophage cells.' *International Immunopharmacology*.