Dibencozide
Bio-Activity Analysis
Bioavailability: Active vs. Synthetic B12
SCIENTIFIC DATA VISUALIZATION
Health Benefits & Sources
Why You Need It
- Boosts Cellular Energy: It is the only form of B12 that works directly inside the mitochondria to help produce energy.
- Metabolic Support: Essential for the metabolism of certain amino acids and fatty acids.
- Genetic Health: Plays a vital role in the synthesis and repair of DNA.
- Methylation Cycle: Supports the body's methylation processes, which are crucial for overall cellular function.
Deep Dive
Dibencozide is a coenzyme form of B12. Think of it as the 'active' version that your body can use immediately without needing to convert it. Its primary claim to fame is its role in the methylmalonyl-CoA mutase reaction. This is a fancy way of saying it helps your mitochondria burn fuel efficiently. Without enough Dibencozide, your body struggles to turn fat and protein into energy, leading to that classic 'B12 deficiency' fatigue. It is particularly important for people with specific genetic mutations (like MTHFR or MMA issues) that make it hard for their bodies to use regular B12 supplements.
Natural Food Sources
Unlike many other vitamins, Dibencozide is not typically found in plants. It is synthesized by bacteria and accumulates in animal tissues. For this reason, it is naturally abundant in organ meats.
| Food | Amount | % DV |
|---|---|---|
| Beef Liver (Cooked) | 60 mcg | 2,500% |
| Clams (Mixed) | 17 mcg | 700% |
| Beef (Ground) | 2.4 mcg | 100% |
| Salmon | 1.8 mcg | 75% |
| Milk | 0.9 mcg | 38% |
Supplementation
Dibencozide is primarily available as a dietary supplement. Because it is the 'active' form, it is often recommended for individuals who have difficulty processing standard Vitamin B12.
- Typical Dosage: Supplements often range from 1,000 mcg to 5,000 mcg per day (sublingual lozenges or drops).
- Who should take it: People experiencing chronic fatigue, those with MTHFR gene variants, or older adults with reduced absorption capabilities.
Top Food Sources
Frequently Asked Questions
Safety & Side Effects
Dibencozide is generally considered safe and well-tolerated. Because it is a water-soluble vitamin, excess amounts are typically excreted through urine (turning it bright yellow).
Cautions:
- Acne: High doses of B12 (including Dibencozide) have been linked to acne flare-ups in some individuals.
- Allergies: People allergic to cobalt or cobalamin should avoid this supplement.
- Interactions: It may interact with certain medications like Metformin, Proton Pump Inhibitors (PPIs), or antibiotics. Consult a doctor if you are on medication.
Scientific References
- [1]Yamada, K. (2022). 'Adenosylcobalamin (Dibencozide): Metabolic and therapeutic implications.' *Journal of Clinical Biochemistry and Nutrition*.
- [2]O'Leary, F., & Samman, S. (2010). 'Vitamin B12: Review of absorption and bioavailability.' *The American Journal of Clinical Nutrition*.
- [3]Shane, B. (2008). 'Folate and Vitamin B12 Metabolism.' *Annual Review of Nutrition*.