Health Guide

Dibencozide

Have you heard of Dibencozide? You might know it better as Adenosylcobalamin, the 'Energy Cobalamin.' While most people are familiar with standard Vitamin B12 (Cyanocobalamin), Dibencozide is a specialized, active form of B12 that plays a critical role in your cellular energy production. Unlike other forms of B12 that focus on the brain and nervous system, Dibencozide is primarily found in the mitochondria—the powerhouse of your cells. It acts like a spark plug for your metabolism, helping your body break down fats and proteins into usable fuel. If you feel sluggish or have trouble converting food into energy, this specific nutrient might be the missing link in your health puzzle.
Evidence BasedDietary Supplement
VERIFIED SOURCE

Bio-Activity Analysis

Bioavailability: Active vs. Synthetic B12

SCIENTIFIC DATA VISUALIZATION

Y-Axis
Direct Usability in Mitochondria
B12 Form

Health Benefits & Sources

Why You Need It

  • Boosts Cellular Energy: It is the only form of B12 that works directly inside the mitochondria to help produce energy.
  • Metabolic Support: Essential for the metabolism of certain amino acids and fatty acids.
  • Genetic Health: Plays a vital role in the synthesis and repair of DNA.
  • Methylation Cycle: Supports the body's methylation processes, which are crucial for overall cellular function.

Deep Dive

Dibencozide is a coenzyme form of B12. Think of it as the 'active' version that your body can use immediately without needing to convert it. Its primary claim to fame is its role in the methylmalonyl-CoA mutase reaction. This is a fancy way of saying it helps your mitochondria burn fuel efficiently. Without enough Dibencozide, your body struggles to turn fat and protein into energy, leading to that classic 'B12 deficiency' fatigue. It is particularly important for people with specific genetic mutations (like MTHFR or MMA issues) that make it hard for their bodies to use regular B12 supplements.

Natural Food Sources

Unlike many other vitamins, Dibencozide is not typically found in plants. It is synthesized by bacteria and accumulates in animal tissues. For this reason, it is naturally abundant in organ meats.

FoodAmount% DV
Beef Liver (Cooked)60 mcg2,500%
Clams (Mixed)17 mcg700%
Beef (Ground)2.4 mcg100%
Salmon1.8 mcg75%
Milk0.9 mcg38%

Supplementation

Dibencozide is primarily available as a dietary supplement. Because it is the 'active' form, it is often recommended for individuals who have difficulty processing standard Vitamin B12.

  • Typical Dosage: Supplements often range from 1,000 mcg to 5,000 mcg per day (sublingual lozenges or drops).
  • Who should take it: People experiencing chronic fatigue, those with MTHFR gene variants, or older adults with reduced absorption capabilities.

Top Food Sources

Beef Liver
The most potent natural source
Clams
Excellent source, low calorie
Beef Steak
Good for general maintenance
Salmon
Provides Omega-3s + B12
Eggs
Contains small amounts, mainly in yolk

Frequently Asked Questions

It is a specific, active form of Vitamin B12. While regular B12 (Cyanocobalamin) must be converted by the body to be used, Dibencozide is already in the form your mitochondria need.
Because it is the only B12 form found inside the mitochondria (the energy factories) of your cells, where it helps convert food into fuel.
Dibencozide is naturally found in significant amounts only in animal products (especially organ meats). Vegans are generally recommended to supplement.
While not a weight-loss pill, by optimizing your metabolism and energy production, it can help your body burn fat more efficiently during exercise.

Safety & Side Effects

Dibencozide is generally considered safe and well-tolerated. Because it is a water-soluble vitamin, excess amounts are typically excreted through urine (turning it bright yellow).

Cautions:

  • Acne: High doses of B12 (including Dibencozide) have been linked to acne flare-ups in some individuals.
  • Allergies: People allergic to cobalt or cobalamin should avoid this supplement.
  • Interactions: It may interact with certain medications like Metformin, Proton Pump Inhibitors (PPIs), or antibiotics. Consult a doctor if you are on medication.

Scientific References

  • [1]Yamada, K. (2022). 'Adenosylcobalamin (Dibencozide): Metabolic and therapeutic implications.' *Journal of Clinical Biochemistry and Nutrition*.
  • [2]O'Leary, F., & Samman, S. (2010). 'Vitamin B12: Review of absorption and bioavailability.' *The American Journal of Clinical Nutrition*.
  • [3]Shane, B. (2008). 'Folate and Vitamin B12 Metabolism.' *Annual Review of Nutrition*.