DrFeb
Health Guide

Diethyl phenethylamine

Diethylphenethylamine (DEPEA) is a synthetic stimulant often sold illicitly in 'dietary supplements' for weight loss and energy. It is chemically related to amphetamine. Unlike essential nutrients found in nature, DEPEA is entirely man-made and carries significant health risks. It is not a food source, but a potent drug-like compound that affects the central nervous system.
Evidence BasedDietary Supplement
Diethyl phenethylamine
VERIFIED SOURCE

Bio-Activity Analysis

Safety Risk vs. Natural Energy Sources

SCIENTIFIC DATA VISUALIZATION

Y-Axis
Safety Risk Level (1-10)
Substance →

Health Benefits & Sources

Why It Is Marketed

[Short-term, risky benefits]

Deep Dive

DEPEA is marketed solely for its ability to act as a rapid fat burner and energy booster. It works by stimulating the release of norepinephrine and dopamine. However, unlike natural stimulants, its effects are harsh and unregulated. There are no long-term health benefits associated with its use; only immediate, temporary pharmacological effects that come with high cardiovascular stress.

Natural Food Sources

None. DEPEA is a synthetic chemical and is not found in any food product.

Supplementation

DEPEA is often found in 'proprietary blends' of weight loss supplements. However, because it is not an approved dietary ingredient, its presence in supplements is illegal in many jurisdictions. Consumers should strictly avoid supplements listing 'Diethylphenethylamine' or proprietary blends that may hide it.

Top Food Sources

None
Synthetic chemical only

Frequently Asked Questions

No. It is a 100% synthetic chemical and cannot be found in fruits, vegetables, or any natural diet.
It is not approved for use as a dietary supplement by the FDA, making its sale illegal in many contexts.
It may suppress appetite temporarily, but the health risks (heart strain, anxiety) far outweigh any potential weight loss.
No. It is classified as a banned substance by the World Anti-Doping Agency (WADA).

Safety & Side Effects

DEPEA is considered a high-risk substance. It can cause severe anxiety, high blood pressure, and heart palpitations. Because it is structurally similar to amphetamine, it may trigger positive results on drug tests. It is not recommended for human consumption.

Scientific References

  • [1]USPSTF Guidelines on Weight Loss
  • [2]WADA Prohibited List
  • [3]FDA Warning Letters regarding DEPEA