Diiodothyronine

Why You Need It

• Metabolic Boost: Increases your basal metabolic rate, helping you burn more calories at rest.
• Liver Health: Promotes fatty acid oxidation in the liver, potentially reducing liver fat accumulation.
• Mitochondrial Function: Enhances the efficiency of your mitochondria (the powerhouses of your cells), generating heat and energy.

Deep Dive

Diodothyronine (T2) is unique because it operates somewhat independently of the traditional T4 to T3 conversion pathway. It works by influencing the expression of genes related to energy expenditure in the mitochondria. It specifically targets the liver to ramp up fat burning (lipolysis) and uncouple respiration, which means energy is burned as heat rather than stored as fat. This makes it a popular area of research for managing weight and improving metabolic flexibility without the systemic side effects of full-blown thyroid hormones.

Natural Food Sources

Unlike iodine, which is found in seafood, Diodothyronine (T2) is not typically found in significant quantities in common foods. It is primarily a metabolic breakdown product of T3 and T4 within the body. However, consuming foods that support healthy thyroid function and hormone conversion is vital.

Supplementation

Since T2 is not a standard nutrient found in food, it is almost exclusively taken as a dietary supplement.

Dosage: Research suggests effective doses range from 50mcg to 300mcg daily. Always start at the lower end to assess tolerance.

Who Should Take It: Individuals looking to support metabolic health, weight loss plateaus, or those with low thyroid function (under medical supervision).