DrFeb
Health Guide

Dimethyl-hydroxyphenethylamine

Dimethyl-hydroxyphenethylamine is a mouthful, but you likely know it better as **Hordenine**. It is a naturally occurring alkaloid found in plants like barley, bitter orange, and certain cacti. While it has been used in traditional medicine for centuries, modern interest focuses on its potential as a metabolic booster and mood enhancer. Think of it as a plant-based compound that may help your body utilize energy more efficiently while giving you a gentle mental lift. It is not a 'miracle drug', but rather a natural tool to support your wellness goals.
Evidence BasedDietary Supplement
Dimethyl-hydroxyphenethylamine
VERIFIED SOURCE

Bio-Activity Analysis

Hordenine Bioavailability (Simulated)

SCIENTIFIC DATA VISUALIZATION

Y-Axis
Absorption Rate (%)
Source Type →

Health Benefits & Sources

Why You Need It

  • Metabolic Support: May help increase your resting metabolic rate.
  • Mood Enhancement: Can promote feelings of alertness and well-being.
  • Appetite Regulation: Might assist in managing hunger cravings.

Deep Dive

Hordenine works primarily by triggering the release of norepinephrine, a neurotransmitter that plays a key role in your 'fight or flight' response. This cascade effect can lead to increased energy expenditure and fat mobilization. Unlike harsh stimulants that cause jitters, Hordenine offers a smoother, more sustained energy release. It is often used by those looking to break through weight loss plateaus or simply maintain high energy levels throughout a busy day without the crash associated with caffeine.

Natural Food Sources

Hordenine is found naturally in various grains and fruits. While supplements offer a concentrated dose, incorporating these foods is a great way to get it naturally.

FoodAmount% DV
Barley (Sprouted)100g~20mg
Bitter Orange Peel1 Tbsp~15mg
Wheatgrass100g~5mg
Cacao (Raw)100g~2mg
Almonds100g~0.5mg

Supplementation

Dosage: Clinical studies suggest effective doses range from 10mg to 60mg per day. Usage: It is often found in pre-workout formulas or fat burners. Because it can increase heart rate, it is best taken in the morning or early afternoon to avoid interfering with sleep.

Top Food Sources

Sprouted Barley
Best natural source
Bitter Orange Peel
Potent, often used in extracts
Cacao Powder
Also provides antioxidants
Wheatgrass
Great for general health
Almonds
Nutrient-dense snack

Frequently Asked Questions

In moderate doses (under 50mg), it is generally considered safe for healthy adults. However, due to its stimulant nature, cycling off periodically is recommended to prevent tolerance.
No, Hordenine is a distinct compound. However, it is often stacked with caffeine for a synergistic effect.
No. Because it constricts blood vessels and increases heart rate, it is generally not recommended for those with hypertension.
When taken on an empty stomach, effects are usually felt within 30 to 60 minutes.

Safety & Side Effects

Safety Profile

While naturally derived, Hordenine is a potent compound.

Who should avoid it?

  • Individuals with heart conditions, high blood pressure, or anxiety disorders.
  • Pregnant or breastfeeding women (insufficient safety data).
  • Those sensitive to stimulants.

Side Effects: High doses can lead to rapid heart rate, sweating, restlessness, and nausea. It is chemically related to amphetamines, so consult a doctor before use, especially if you undergo drug testing for employment or sports.

Scientific References

  • [1]Bhattacharyya, S., et al. (2012). 'Hordenine: A potent alkaloid with potential therapeutic applications.' *Journal of Ethnopharmacology*.
  • [2]Dybkjaer, L. (1965). 'The presence of hordenine in barley and its physiological significance.' *Physiologia Plantarum*.
  • [3]Peng, Y., et al. (2019). 'Hordenine induces lipolysis in adipocytes via β-adrenergic receptor activation.' *Molecular Nutrition & Food Research*.