Health Guide

Dimethylglycine

Dimethylglycine (DMG) is a derivative of the amino acid glycine, naturally found in the body and in various foods. Often referred to as a 'bio-regulator,' it plays a crucial role in cellular metabolism and methylation processes. While your body produces it, supplemental DMG is often used to boost mental clarity, physical endurance, and immune system responsiveness. It acts as a metabolic buffer, helping the body utilize oxygen more efficiently and manage stress at a cellular level.

Evidence BasedDietary Supplement

VERIFIED SOURCE

Bio-Activity Analysis

DMG Bioavailability Source

SCIENTIFIC DATA VISUALIZATION

Y-Axis

Absorption Efficiency

Source Type →

Health Benefits & Sources

Why You Need It

Enhanced Energy Production: Supports the mitochondria (the powerhouses of your cells) to produce energy more efficiently.
Cognitive Support: May help improve focus, speech, and behavior in some individuals.
Immune Modulation: Helps the immune system respond more effectively to stressors.

Deep Dive

DMG functions as a methyl donor in the body. This is a vital chemical process (methylation) that influences everything from DNA repair to neurotransmitter synthesis. By donating a methyl group, DMG helps convert homocysteine into methionine, which supports cardiovascular health. Furthermore, DMG is involved in the synthesis of SAMe (S-adenosylmethionine), a compound critical for mood regulation and joint health. Its ability to improve the 'efficiency' of cellular respiration means your body gets more energy out of the fuel you provide.

Natural Food Sources

While DMG is found in almost all living cells, concentrated sources are primarily animal-based. However, it is present in the life cycle of plants.

Food	Amount	% DV
Beef Liver	150mg	High
Pork Loin	80mg	Moderate
Salmon	60mg	Moderate
Eggs	40mg	Moderate
Legumes	20mg	Low

Supplementation

Dosage: Common dosages range from 50mg to 300mg daily. It is often sold as a liquid or capsule. Who should take it: It is popular among athletes for endurance and parents of children with developmental delays (under professional guidance), though the latter use is controversial and requires medical supervision. It is generally considered safe for short-term use in healthy adults.

Top Food Sources

Beef Liver

Approx 150mg per 3oz serving

Pork Loin

Approx 80mg per serving

Salmon

Rich in amino acids

Eggs

Found in the yolk

Legumes

Present in sprouts

Frequently Asked Questions

No. TMG (Trimethylglycine) has three methyl groups, while DMG has two. TMG is primarily used for liver health and lowering homocysteine, whereas DMG is often used for immune and metabolic support.

Some earlier studies suggested benefits for speech and behavior, but current scientific consensus is mixed. Always consult a specialist before using it for this purpose.

DMG inhibits this enzyme, which can theoretically improve oxygen utilization. This is why it is popular in endurance sports.

Yes, it often works synergistically with B6, B12, and Folate to support methylation pathways.

Safety & Side Effects

DMG is generally recognized as safe, but as a concentrated chemical, caution is advised.

Who should avoid it:

Pregnant or breastfeeding women: Due to a lack of safety data.
People on antipsychotic medication: DMG can interact with these drugs.
Children: Should only be administered under strict medical guidance.

Side Effects:

Skin Irritation: When taken in liquid form, it can cause irritation if applied to the skin.
Gastrointestinal upset: Nausea or stomach cramps if taken on an empty stomach.
Insomnia: Due to its metabolic boost, it is best taken earlier in the day.

Scientific References

[1]Krabbe, S., et al. (2005). 'The effect of dimethylglycine on physical performance.' *International Journal of Sport Nutrition*.
[2]Kidd, P. M. (2001). 'Dimethylglycine (DMG): A review of the scientific literature.' *Alternative Medicine Review*.
[3]Barker, H. A. (1981). 'Amino acid degradation by anaerobic bacteria.' *Annual Review of Biochemistry*.