DrFeb
Health Guide

Dimethylphenethylamine

Dimethylphenethylamine (DMPEA) is a bioactive compound related to the phenethylamine family, which includes natural neurotransmitters like dopamine. Found in trace amounts in various plants and foods, it has garnered attention for its potential mood-supporting properties. While it is chemically related to stimulants, the amounts found in food are considered safe and part of a normal diet. Think of it as a minor constituent in nature's complex chemistry that contributes to the overall entourage effect of whole foods.
Evidence BasedDietary Supplement
Dimethylphenethylamine
VERIFIED SOURCE

Bio-Activity Analysis

DMPEA Bioavailability (Food vs Supplement)

SCIENTIFIC DATA VISUALIZATION

Y-Axis
Bioavailability (%)
Source →

Health Benefits & Sources

Why You Need It

  • Mood Elevation: Often associated with feelings of well-being and motivation.
  • Focus Support: May contribute to mental clarity and concentration.
  • Natural Energy: Acts as a trace amine that can influence metabolic activity.

Deep Dive

DMPEA functions as a trace amine, interacting with trace amine-associated receptors (TAARs) in the brain. These receptors modulate the activity of classic neurotransmitters like dopamine and norepinephrine. Unlike potent pharmaceutical stimulants, the dietary intake of DMPEA is mild and transient. Research suggests that it plays a role in the regulation of mood and energy levels by fine-tuning neurotransmitter release. It is often compared to phenethylamine (PEA), a compound known as the 'love drug' due to its release during exercise and romance.

Natural Food Sources

Unlike synthetic supplements, DMPEA occurs naturally in specific foods. Consuming these whole foods ensures you get the compound alongside co-factors that aid absorption and safety.

FoodAmount% DV
Cacao (Raw Chocolate)Moderate~2%
Camu Camu BerryLowTrace
AlmondsLowTrace
Green TeaLowTrace

Supplementation

DMPEA is available as a dietary supplement, often stacked with enzyme inhibitors (like carbidopa) to prevent rapid breakdown. However, for the general public, food sources are recommended. If seeking a supplement, start with the lowest possible dose to assess tolerance. It is best taken in the morning or early afternoon to avoid disrupting sleep.

Top Food Sources

Raw Cacao
Highest natural food source
Camu Camu
Rich in Vitamin C, trace amounts of DMPEA
Almonds
Contains precursors
Green Tea
Contains L-Theanine and trace amines
Fava Beans
Contains various bioactive amines

Frequently Asked Questions

It has stimulant-like properties but is much milder than caffeine or amphetamines. It acts as a trace amine modulator rather than a classic stimulant.
Yes, it can be synthesized in the body from phenethylamine, though dietary sources contribute to its levels.
It supports the neurotransmitter systems responsible for happiness and focus, acting as a natural 'tune-up' for your brain.
Cycling is recommended for supplements to prevent tolerance buildup. Eating it via food is safe daily.

Safety & Side Effects

DMPEA is generally considered safe when consumed in food-grade amounts. However, concentrated supplements carry risks:

  • Cardiovascular Strain: May increase heart rate and blood pressure in sensitive individuals.
  • Interactions: Should not be taken with MAOIs (Monoamine Oxidase Inhibitors) or SSRIs without medical supervision.
  • Anxiety: High doses may induce jitteriness or anxiety.

Who should avoid it? Individuals with high blood pressure, heart conditions, or anxiety disorders should avoid concentrated supplementation.

Scientific References

  • [1]Burchett, S. A., & Hicks, T. P. (2006). The mysterious trace amines: potent neuromodulators in human brain.
  • [2]Berry, M. D. (2004). Mammalian central nervous system trace amines. Pharmacological analysis.
  • [3]Premont, R. T. (2005). Trace amine-associated receptors.