DL-phenylalanine

Bio-Activity Analysis
Impact on Pain Threshold
SCIENTIFIC DATA VISUALIZATION
Health Benefits & Sources
Why You Need It
- Mood & Motivation Support: Helps the production of 'feel-good' neurotransmitters.
- Chronic Pain Management: The D-form may block enzymes that break down the body's natural painkillers.
- Adrenal Stress Support: May help the adrenal glands produce stress hormones during difficult times.
Deep Dive
DLPA works by a fascinating mechanism. The L-phenylalanine component is a precursor to norepinephrine and dopamine—neurotransmitters responsible for focus, energy, and a positive outlook. This is why it is often called a natural 'upper.' The D-phenylalanine component, which does not occur naturally in food, inhibits enzymes called enkephalinase. These enzymes usually break down the body's natural pain-relieving chemicals (endorphins). By slowing this breakdown, the D-form may help elevate pain threshold and prolong relief. When taken together, they provide a comprehensive boost to both your mental state and physical comfort levels.
Natural Food Sources
It is important to note that DL-Phenylalanine as a supplement contains the D-isomer, which is not found in nature. However, you can obtain L-Phenylalanine from high-protein foods. To get the full 'DL' effect, you must supplement.
| Food | Amount (approx) | % DV | |---|---|---| | Beef (3oz) | 900mg | 100% | | Chicken (3oz) | 800mg | 90% | | Tofu (1/2 cup) | 500mg | 55% | | Salmon (3oz) | 850mg | 95% | | Peanut Butter (2 tbsp) | 400mg | 45% |
Supplementation
DLPA is most commonly found in capsule form. It is typically used as a cycle rather than a daily staple—often taken for 2-4 weeks during periods of low mood or physical pain, then discontinued to prevent the body from building tolerance.
Top Food Sources
Frequently Asked Questions
Safety & Side Effects
WARNING: DL-Phenylalanine should be avoided by individuals with Phenylketonuria (PKU), a rare genetic condition where the body cannot process phenylalanine.
Interactions: Do not take DLPA if you are currently taking antidepressants (MAOIs or SSRIs), as it can increase the risk of a condition called Serotonin Syndrome. It may also interact with thyroid medication. Consult a doctor if you have high blood pressure, as phenylalanine can occasionally increase blood pressure in sensitive individuals.
Scientific References
- [1]Birkmayer, W., & Birkmayer, J. G. (1986). 'DL-Phenylalanine: A Potentiator of the Endorphin System.' *Journal of Orthomolecular Medicine*.
- [2]Beck, S. (1985). 'The use of D- and DL-phenylalanine in chronic pain.' *Journal of Neurological and Orthopaedic Medicine and Surgery*.
- [3]National Institutes of Health (NIH) Office of Dietary Supplements: 'Phenylalanine Fact Sheet for Health Professionals.'