DrFeb
Health Guide

Fadogia agrestis

Fadogia agrestis is a shrub native to Nigeria and other African regions, traditionally used in folk medicine for its potential aphrodisiac and performance-enhancing properties. Often called the 'African Viagra,' this supplement has gained popularity in the fitness and biohacking communities for its reported ability to boost testosterone levels, enhance libido, and improve physical performance. Unlike essential vitamins or minerals, Fadogia agrestis is a herbal extract containing active compounds like alkaloids and saponins. It works by stimulating the body's natural production of luteinizing hormone (LH), which in turn signals the testes to produce more testosterone. This guide explores the science behind this intriguing herb, its benefits, and crucial safety considerations.
Evidence BasedDietary Supplement
Fadogia agrestis
VERIFIED SOURCE

Bio-Activity Analysis

Mechanism of Action: LH & Testosterone Pathway

SCIENTIFIC DATA VISUALIZATION

Y-Axis
Relative Increase
Hormone Level →

Health Benefits & Sources

Why You Need It

  • Testosterone Boost: Increases the production of luteinizing hormone (LH), leading to higher testosterone levels.
  • Enhanced Libido: Traditionally used as an aphrodisiac to improve sexual desire and performance.
  • Physical Performance: May increase muscle strength, endurance, and recovery, making it popular among athletes.
  • Fertility Support: Potential positive effects on sperm quality and motility.

Deep Dive

The primary mechanism of Fadogia agrestis is its stimulation of luteinizing hormone (LH) release from the pituitary gland. LH acts as a direct signal to the Leydig cells in the testes to ramp up testosterone production. This is why it is often compared to Tongkat Ali (Eurycoma longifolia) but with a more direct impact on LH. Users report feeling increased energy, motivation, and a stronger 'pump' during workouts. However, human clinical trials are limited, and much of the evidence is anecdotal or derived from animal studies. The active compounds are believed to be alkaloids, which act on the hypothalamic-pituitary-gonadal axis.

Natural Food Sources

Fadogia agrestis is a specific botanical herb and does not have natural food sources like fruits or vegetables. It grows wild in the African bush and is harvested for extraction. To support natural testosterone production through diet, focus on foods rich in Zinc, Vitamin D, and healthy fats.

Supplementation

  • Dosage: There is no official Recommended Dietary Allowance (RDA). Common anecdotal dosage ranges from 300mg to 600mg daily of a standardized extract (often 10:1 or 20:1 ratio).
  • Cycling: Due to limited long-term safety data, it is highly recommended to cycle the supplement. A common cycle is 2 weeks on, 1 week off, or 4 weeks on, 2 weeks off.
  • Who Should Take It: Adult men looking to support low testosterone levels or athletic performance. It is not recommended for women, children, or individuals with hormone-sensitive conditions.

Top Food Sources

N/A (Herbal Extract)
Not found in food
Oysters (Zinc)
Supports natural T production
Egg Yolks
Rich in cholesterol (T precursor)
Fatty Fish
Vitamin D & Omega-3s
Brazil Nuts
Selenium for hormone health

Frequently Asked Questions

Anecdotal evidence is strong, but human clinical data is scarce. It works by increasing LH, which should raise testosterone, but long-term safety and efficacy are not well-established.
Many users report feeling effects within 1-2 weeks, particularly regarding libido and energy levels.
No. It is designed to influence male androgen pathways. Its effects on female hormones are unknown and potentially harmful.
Yes, this is a common stack. However, this increases the risk of side effects. Start with low doses of each and monitor your body's response carefully.

Safety & Side Effects

Safety is a major concern with Fadogia agrestis. While many users report benefits, there are significant potential side effects to consider:

  • Testicular Toxicity: Animal studies have shown that high doses can lead to testicular damage, swelling, and atrophy over time. This is the most significant risk.
  • Liver Health: There are anecdotal reports of elevated liver enzymes, suggesting potential hepatotoxicity. It is crucial to monitor liver function if using this supplement.
  • Prostate Issues: By increasing testosterone, it could potentially exacerbate conditions like Benign Prostatic Hyperplasia (BPH).
  • Interactions: It may interact with medications that affect hormone levels or blood pressure.

It is strongly advised to consult a healthcare professional before starting Fadogia agrestis, especially if you have pre-existing health conditions.

Scientific References

  • [1]Yakubu, M. T., et al. (2008). 'Effect of Fadogia agrestis (Schweinf. Ex Heirn) aqueous extract on the reproductive hormones of male rats.' *Journal of Ethnopharmacology*.
  • [2]Yakubu, M. T., & Akanji, M. A. (2009). 'Effect of aqueous extract of Fadogia agrestis (Schweinf. Ex Heirn) stem on some reproductive parameters of male rats.' *African Journal of Reproductive Health*.
  • [3]Abdulazeez, A. T., et al. (2019). 'Toxicological assessment of Fadogia agrestis stem extract in male Wistar rats.' *Comparative Clinical Pathology*.
  • [4]PubMed Database: Search for 'Fadogia agrestis testosterone'