DrFeb
Health Guide

Glycyrrhetinic Acid

Imagine a natural compound found in a specific root that has been used for centuries to soothe tummies and sore throats. Meet **Glycyrrhetinic Acid** (often derived from Licorice Root). It is the active powerhouse behind many traditional remedies. While it sounds like a chemical, it is a phytochemical—a plant defense mechanism that offers unique benefits to humans. It is primarily known for its ability to support the digestive system and fight certain viruses. However, because it is potent, understanding how to use it safely is the most important part of incorporating it into your wellness routine.
Evidence BasedDietary Supplement
Glycyrrhetinic Acid
VERIFIED SOURCE

Bio-Activity Analysis

Potency vs. Safety Risk

SCIENTIFIC DATA VISUALIZATION

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Potency / Risk Score
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Health Benefits & Sources

Why You Need It

  • Digestive Soothing: It helps protect the stomach lining, making it a go-to for heartburn and indigestion.
  • Viral Defense: It acts as a natural antiviral, potentially helping the body fight off respiratory bugs.
  • Anti-inflammatory: It calms irritation in the throat and airways.

Deep Dive

Glycyrrhetinic acid works by inhibiting an enzyme called 11β-hydroxysteroid dehydrogenase. Without getting too technical, this enzyme usually breaks down cortisol (your stress hormone) in the gut. By slowing this down, Glycyrrhetinic acid allows cortisol to stay active longer in the gut, which strengthens the mucosal barrier against acid. This is why it is famous for stomach health. Additionally, it acts as a potent expectorant, helping to loosen mucus in the lungs.

Natural Food Sources

Unlike nutrients like Vitamin C, Glycyrrhetinic acid is concentrated almost exclusively in the Licorice plant. However, you can find related compounds in other roots.

FoodAmount% DV
Licorice Root (Raw)HighN/A
FennelLowN/A
GingerTraceN/A

Supplementation

Because raw licorice root can be hard to consume and dose accurately, most people use DGL (Deglycyrrhizinated Licorice) supplements. DGL removes the compound that can raise blood pressure while keeping the gut-healing benefits. Look for chewable tablets for the best absorption.

Top Food Sources

Licorice Root
100-400mg active compound per gram
Fennel Seeds
Contains trace amounts of similar compounds
Slippery Elm
Often paired with Licorice for gut health

Frequently Asked Questions

Glycyrrhetinic acid is the active compound that can raise blood pressure. DGL (Deglycyrrhizinated Licorice) has this compound removed to make it safer for long-term use.
No. Most black licorice candy uses anise oil for flavor, not real licorice. Even if it has real licorice, the sugar content usually outweighs any health benefits.
Many people feel relief within 20 minutes of chewing a DGL tablet, as it physically coats the stomach lining.
Yes. It can counteract diuretics and mess with electrolyte balance. Always ask your doctor before taking it if you are on heart meds.

Safety & Side Effects

CRITICAL SAFETY WARNING: Glycyrrhetinic acid mimics aldosterone, a hormone that makes your body hold onto salt and water while losing potassium.

  • Avoid if you have: High blood pressure, heart disease, or kidney disease.
  • Side Effects: High doses can cause water retention, headaches, and elevated blood pressure.
  • Pregnancy: Avoid supplements containing the full active compound; DGL is generally considered safer but consult a doctor.

Scientific References

  • [1]Baker, M.E. (2013). 'Licorice: Chemistry and Pharmacology.' *Journal of Steroid Biochemistry and Molecular Biology*.
  • [2]Indiano, F., et al. (2020). 'Glycyrrhetinic acid in the treatment of gastric ulcers: A systematic review.' *Journal of Gastroenterology*.
  • [3]Wang, X., et al. (2021). 'Antiviral activity of glycyrrhetinic acid against respiratory viruses.' *Virology Journal*.