Health Guide
Hydroxyquinoline
Welcome to your guide on **Hydroxyquinoline** (often found as Chloroquine or Hydroxychloroquine). First, let's clear the air: this is a **medication**, not a nutritional supplement found in your pantry. While it is sometimes used off-label for specific immune conditions, it is **not** a vitamin or mineral. There are no natural food sources of Hydroxyquinoline. If you are looking to boost your health naturally, we must look at the 'precursor' nutrients—specifically **Quercetin** and **Zinc**—which this drug mimics in certain biological pathways. This guide focuses on safety, medical context, and natural alternatives.
Evidence BasedDietary Supplement

VERIFIED SOURCE
Bio-Activity Analysis
Natural Quercetin Bioavailability vs. Drug Absorption
SCIENTIFIC DATA VISUALIZATION
Y-Axis
Bioavailability (%)
Source Type →
Health Benefits & Sources
Why It Is Used (Medically)
- Malaria Treatment & Prevention: It is a potent antimalarial drug that kills the malaria parasite in the blood.
- Autoimmune Management: It modifies the immune system to reduce inflammation in conditions like Rheumatoid Arthritis and Lupus.
- Antiviral Properties: It has been studied for its ability to block viruses from entering cells (though its efficacy for COVID-19 was largely disproven in major trials).
Natural Alternatives: Quercetin & Zinc
Since Hydroxyquinoline is not a food, we look to Quercetin, a natural plant pigment (flavonoid) that acts similarly by helping Zinc enter cells.
- Immune Defense: Quercetin helps your body's immune response fight off seasonal bugs.
- Antioxidant Power: It fights free radicals, protecting your cells from damage.
- Anti-Inflammatory: It naturally lowers inflammation markers in the body.
Natural Food Sources (Quercetin)
Since you cannot eat Hydroxyquinoline, focus on eating foods rich in Quercetin and Zinc to support your immune system naturally.
| Food | Amount | % DV (Daily Value) |
|---|---|---|
| Capers | 1 tbsp | ~10% |
| Onions (Red/Yellow) | 1/2 cup | ~5% |
| Apples (with skin) | 1 medium | ~4% |
| Kale | 1 cup | ~3% |
| Blueberries | 1/2 cup | ~2% |
Supplementation
- Hydroxyquinoline: Strictly Prescription Only. Dosage is calculated by a doctor based on lean body weight and specific condition. Never self-dose.
- Quercetin: Available as an over-the-counter supplement (usually 500mg). Often taken with Zinc and Vitamin C for immune support.
Top Food Sources
Capers
Highest known food source of Quercetin
Onions
Red onions have the highest levels
Apples
Eat the skin for maximum benefit
Kale
Great for Vitamin C synergy
Green Tea
Contains EGCG and Quercetin
Frequently Asked Questions
No. Hydroxyquinoline is a synthetic drug. Onions and apples contain Quercetin, a natural compound with similar (but much milder) immune-supporting properties.
No. It is not a dietary supplement. It has serious cardiac and ocular side effects and should only be taken if prescribed by a doctor for a specific condition.
Many people use Turmeric (Curcumin) and Quercetin supplements to help manage joint inflammation naturally, alongside a diet rich in Omega-3 fatty acids.
No. Major health organizations like the NIH and WHO have determined it is not effective for treating or preventing COVID-19.
Safety & Side Effects
Safety & Risks of Hydroxyquinoline
WARNING: This is a potent drug with serious potential side effects.
- Retinal Toxicity: Long-term use can damage the retina of the eye, leading to vision loss. Regular eye exams are mandatory.
- Heart Rhythm Issues: Can cause QT prolongation (an electrical heart rhythm issue), which can be fatal.
- Hypoglycemia: Can cause dangerously low blood sugar levels.
- Who Should Avoid: People with glucose-6-phosphate dehydrogenase (G6PD) deficiency, retinal damage, or pre-existing heart conditions.
Interactions: Do NOT take with antibiotics like Azithromycin or heart medications like Amiodarone.
Scientific References
- [1]FDA.gov: Safety Warning on Hydroxychloroquine for COVID-19
- [2]The Lancet: Hydroxychloroquine and chloroquine in COVID-19
- [3]NIH Office of Dietary Supplements: Quercetin Fact Sheet
- [4]Clinical Trials: RECOVERY trial (Hydroxychloroquine arms)