isoleucine alpha-ketoglutarate

Bio-Activity Analysis
Natural vs. Supplement Concentration
SCIENTIFIC DATA VISUALIZATION
Health Benefits & Sources
Why You Need It
- Boosts Athletic Performance: Helps fuel muscles and reduce fatigue.
- Supports Healthy Aging: May help maintain muscle mass as you get older.
- Enhances Cellular Energy: Vital for the Krebs cycle, which creates ATP (energy).
How It Works
Isoleucine alpha-ketoglutarate acts as a 'double agent' for your health. First, the Isoleucine part provides the necessary amino acids to repair and build muscle tissue, specifically targeting the 'fast-twitch' fibers used in strength and sprinting. Second, the Alpha-Ketoglutarate (AKG) component acts as a nitrogen scavenger and a precursor to glutamate, which is crucial for protein synthesis and metabolic waste removal. By combining them, your body gets both the building blocks and the metabolic spark plugs needed for peak physical output and recovery.
Natural Food Sources
While you can find AKG in small amounts in certain foods, it is important to note that Isoleucine Alpha-Ketoglutarate as a specific supplement is primarily synthetic. However, you can naturally boost your body's production of these components through diet:
| Food | Amount (Approx) | Primary Component |
|---|---|---|
| Citrus Fruits | Moderate | Alpha-Ketoglutarate precursor |
| Meat/Fish | High | Isoleucine |
| Eggs | High | Isoleucine |
| Nuts/Seeds | Moderate | Isoleucine |
Supplementation
Because the natural concentration in food is low, those seeking the specific ergogenic (performance-enhancing) benefits usually turn to supplements.
- Typical Dosage: Scientific studies often use dosages ranging from 500mg to 2000mg per day, usually taken pre-workout or split into two doses.
- Who Should Take It: Athletes, bodybuilders, or older adults looking to preserve muscle mass.
Top Food Sources
Frequently Asked Questions
Safety & Side Effects
Safety Profile
Isoleucine alpha-ketoglutarate is generally considered safe for healthy adults at recommended dosages. However, because it influences nitrogen levels in the body, caution is advised.
Who should avoid it?
- Individuals with Kidney Disease: The kidneys process nitrogen waste from amino acids. High doses could strain compromised kidneys.
- Individuals with Liver Disease: The liver metabolizes AKG.
- Pregnant or Breastfeeding Women: There is insufficient safety data for this specific compound.
Potential Side Effects:
- Mild gastrointestinal upset (nausea, stomach cramps).
- Potential drop in blood sugar levels (hypoglycemia).
Interactions:
- May interact with L-dopa (Parkinson's medication) or Ammonia-absorbing drugs. Always consult a doctor before starting.
Scientific References
- [1]Sun, H., et al. (2020). 'Effects of alpha-ketoglutarate on vertebrates: A review.' *Journal of Animal Science*.
- [2]Doi, M., et al. (2022). 'Alpha-ketoglutarate (AKG) and Athletic Performance.' *Nutrients*.
- [3]Zhang, L., et al. (2021). 'The role of α-ketoglutarate in cellular metabolism and aging.' *Cell Metabolism Reviews*.