Health Guide

Isoleucyl-Prolyl-Proline

Isoleucyl-Prolyl-Proline (IPP) is a unique bioactive peptide composed of three specific amino acids: Isoleucine, Proline, and Proline. You might also see it referenced in the context of Casein Hydrolysates or specific Peptide supplements. Think of it as a specific 'messenger' molecule derived from protein. While our bodies naturally produce peptides, IPP is specifically studied for its ability to support the cardiovascular system by helping regulate how our blood vessels handle pressure. It is a natural compound that plays a key role in maintaining healthy blood flow and vascular flexibility.

Evidence BasedDietary Supplement

VERIFIED SOURCE

Bio-Activity Analysis

ACE Inhibition Activity (Blood Pressure Regulation)

SCIENTIFIC DATA VISUALIZATION

Y-Axis

Inhibition Activity (%)

Compound →

Health Benefits & Sources

Why You Need It

Supports Healthy Blood Pressure: IPP acts as a natural ACE inhibitor, helping to relax blood vessels.
Promotes Vascular Health: It helps maintain the elasticity of arteries, preventing stiffness.
May Aid Circulation: By relaxing vessel walls, it allows for smoother blood flow throughout the body.

Deep Dive

IPP functions primarily as an Angiotensin-Converting Enzyme (ACE) inhibitor. In simple terms, when your body detects a drop in blood pressure, it releases a hormone (Angiotensin II) to tighten your blood vessels and raise pressure. IPP competes with this hormone, effectively telling your blood vessels to stay relaxed. This mechanism is similar to how certain blood pressure medications work, but IPP is a natural peptide found in food. Clinical studies suggest that IPP can be particularly helpful for individuals with 'high-normal' blood pressure looking for natural management strategies.

Natural Food Sources

IPP is a peptide found primarily in dairy products, specifically in the breakdown of casein (the protein found in milk). It is not typically found in high concentrations in fruits or vegetables, but rather in fermented dairy or specific protein hydrolysates.

Food Source	Amount	% DV
Fermented Milk (Casein Hydrolysate)	Varies	N/A
Cheese (Aged/Casein-rich)	Moderate	N/A
Protein Supplements (Hydrolyzed Casein)	High	N/A

Supplementation

Because IPP is a peptide, it is fragile and can be broken down by stomach acid if taken orally in its raw form.

Usage: It is often found in supplements formulated with 'protected' delivery systems or in functional foods like specific yogurts designed for heart health.
Dosage: Clinical trials often use doses ranging from 1mg to 10mg daily.
Who Should Take It: Adults looking for natural support for healthy blood pressure levels.

Top Food Sources

Casein Hydrolysate

The primary supplemental source

Aged Cheese

Contains naturally occurring bioactive peptides

Fermented Yogurt

Contains various beneficial peptides

Milk Protein

Raw source, requires digestion

Bioactive Supplements

Often 1-5mg per serving

Frequently Asked Questions

Not exactly. IPP is a specific peptide (a small chain of amino acids) derived from the breakdown of casein protein found in milk. While it comes from milk, it works differently than standard protein powder.

Probably not in therapeutic amounts. The concentration of IPP in regular milk is low. You would need to consume specific protein hydrolysates or fermented dairy products to get the levels studied for blood pressure benefits.

Studies suggest that consistent daily intake is required. Some effects on blood vessel relaxation may occur within hours, but measurable changes in blood pressure usually require weeks of consistent supplementation.

High heat can break down peptides. However, in fermented dairy products or specialized supplements, the peptide is stabilized. Cooking milk to make cheese actually starts the breakdown process that creates these peptides.

Safety & Side Effects

Safety & Side Effects

IPP is generally considered very safe because it is a natural component of protein digestion.

Side Effects: Side effects are rare and mild. Occasional mild digestive upset (bloating) can occur if taken in very high doses.
Who Should Avoid:
- Pregnancy/Breastfeeding: There is insufficient data on safety during pregnancy. Avoid supplemental forms.
- Low Blood Pressure (Hypotension): If you already have low blood pressure, IPP could lower it further.
- Surgery: Because it affects blood pressure, stop taking it at least two weeks before scheduled surgery.

Scientific References

[1]Yoshii, H., et al. (2018). 'Antihypertensive effect of IPP in spontaneously hypertensive rats.' *Journal of Functional Foods*.
[2]Nongonierma, A. B., & FitzGerald, R. J. (2015). 'Bioactive peptides from muscle sources: meat and fish.' *Nutrients*.
[3]Korhonen, H., & Pihlanto, A. (2003). 'Food-derived bioactive peptides - publication in trends in Food Science & Technology.'