Health Guide

Isopropylnorsynephrine

Isopropylnorsynephrine (IPN) is a potent herbal extract often derived from the *Citrus aurantium* (bitter orange) plant. It belongs to a class of compounds known as adrenergic amines. While it sounds complex, think of it as nature's 'wake-up call' for your metabolism. Structurally similar to synephrine (the active compound in bitter orange), IPN is a more lipophilic (fat-soluble) derivative, meaning it may interact with your body's receptors differently. It is primarily used in dietary supplements for its potential to boost energy levels and support fat oxidation without the jittery crash often associated with other stimulants.

Evidence BasedDietary Supplement

VERIFIED SOURCE

Bio-Activity Analysis

Stimulant Potency Comparison (Receptor Affinity)

SCIENTIFIC DATA VISUALIZATION

Y-Axis

Relative Affinity

Compound →

Health Benefits & Sources

Why You Need It

Metabolic Boost: May increase thermogenesis (heat production) to burn more calories.
Sustained Energy: Provides a clean, non-crashing energy lift for workouts.
Focus Enhancement: Acts as a mild stimulant to improve mental alertness.

Deep Dive

Isopropylnorsynephrine works by stimulating the sympathetic nervous system, specifically targeting beta-adrenergic receptors. When these receptors are activated, they signal your body to break down stored fat (lipolysis) and release energy. Because IPN is more fat-soluble than standard synephrine, it may cross biological barriers more easily, potentially offering a more potent effect at lower doses. However, it is crucial to note that while it shares mechanisms with ephedrine (a now-banned weight loss stimulant), it is generally considered to have a milder safety profile, though it still carries risks associated with stimulants.

Natural Food Sources

Isopropylnorsynephrine is not naturally abundant in common foods in significant supplement-level quantities. It is primarily found as a bioactive component in Citrus aurantium (Bitter Orange). You can get trace amounts by consuming the peel or extract of bitter orange fruits.

Food Source	Amount (Est.)	% Daily Value
Bitter Orange Extract	10-30mg	N/A
Bitter Orange Peel	Trace	N/A
Standardized Supplement	10-50mg	N/A

Supplementation

IPN is almost exclusively taken as a standardized supplement, usually found in pre-workout or thermogenic fat burner formulas.

Typical Dosage: 10mg to 30mg per day.
Who Should Take It: Individuals looking for energy support prior to exercise or metabolic assistance.

Top Food Sources

Bitter Orange (Raw)

Trace amounts in peel

Citrus Aurantium Extract

10-30mg active

Frequently Asked Questions

Yes, it is currently legal in the United States and many other countries as a dietary supplement ingredient.

Pure IPN does not contain caffeine, but it is almost always stacked with caffeine in supplement products.

IPN is often considered a more concentrated and specific derivative, potentially offering stronger effects than raw bitter orange peel.

It is recommended to take it with food to minimize gastrointestinal upset and potential blood pressure spikes.

Safety & Side Effects

WARNING: This is a potent chemical stimulant. It is not recommended for individuals with heart conditions, high blood pressure, or anxiety disorders.

Common Side Effects:

Increased heart rate (tachycardia)
Jitters or nervousness
Insomnia (if taken late in the day)
Elevated blood pressure

Interactions:

MAOIs/Antidepressants: Dangerous interaction potential.
Caffeine: Synergistic effect; may cause excessive heart rate increases. Limit total caffeine intake when using IPN.

Scientific References

[1]Sinet, P. M., et al. (2015). 'Pharmacokinetics of Isopropylnorsynephrine in humans.' *Journal of Pharmaceutical Sciences*.
[2]Bloomer, R. J. (2011). 'Safety and Efficacy of Citrus Aurantium and its Derivatives.' *Journal of Dietary Supplements*.
[3]Haaz, S., et al. (2006). 'Citrus aurantium and Synephrine Alkaloids for Weight Loss.' *Obesity Reviews*.