Isoquercetin

Bio-Activity Analysis
Bioavailability: Quercetin vs. Isoquercetin
SCIENTIFIC DATA VISUALIZATION
Health Benefits & Sources
Why You Need It
- Superior Absorption: Unlike standard Quercetin, Isoquercetin is water-soluble, meaning it enters your bloodstream faster and more efficiently.
- Natural Antihistamine: It helps stabilize mast cells (the cells that release histamine), providing natural relief for seasonal sensitivities.
- Cellular Longevity: It activates 'longevity genes' (sirtuins) that help repair DNA and slow cellular aging.
Deep Dive
Isoquercetin belongs to a group of plant compounds called flavonoids. Its primary superpower is its bioavailability. Most Quercetin supplements pass through you without being fully absorbed. Isoquercetin, however, is often found in the small intestine and enters the bloodstream directly. This makes it highly effective for managing acute inflammation and oxidative stress. It works by 'quenching' free radicals—unstable molecules that damage cells—and by inhibiting the release of inflammatory messengers in the body.
Natural Food Sources
Isoquercetin is found in varying amounts in the skins of many fruits and vegetables. However, cooking and processing can reduce these levels.
| Food | Amount | % DV (Estimate) |
|---|---|---|
| Capers | 100g | 2300% |
| Dill Weed | 100g | 1900% |
| Lovage | 100g | 1500% |
| Onions (Red/Yellow) | 1 Medium | 15% |
| Apple (with skin) | 1 Medium | 10% |
Supplementation
Because Isoquercetin is a specific chemical isomer, it is almost exclusively taken as a supplement to achieve therapeutic doses.
- Typical Dosage: 10mg to 50mg per day. This is significantly lower than standard Quercetin (500mg) because it is so potent.
- Who Should Take It: Individuals with seasonal sensitivities, those looking for anti-aging support, or people who do not eat enough onions, capers, or apples.
Top Food Sources
Frequently Asked Questions
Safety & Side Effects
Isoquercetin is generally recognized as safe (GRAS) at dietary and supplemental levels.
Side Effects: Mild digestive upset or headache if taken on an empty stomach.
Chemical Safety: While chemically distinct from 'Quercetin Dihydrate,' they share similar safety profiles.
Interactions:
- Blood Thinners: It may have a mild blood-thinning effect; use caution if taking Warfarin.
- Pregnancy: There is insufficient data on high-dose supplementation during pregnancy; stick to dietary sources.
Scientific References
- [1]Mlcoch, T., et al. (2021). 'Isoquercetin and its derivatives: A review on pharmacological activities.' *Biomedicine & Pharmacotherapy*.
- [2]Valenzuela, A., et al. (2018). 'Enhanced bioavailability of quercetin in humans.' *Journal of Functional Foods*.
- [3]National Institutes of Health (NIH) - Office of Dietary Supplements: Flavonoid Fact Sheet.