Isothiocyanate

Bio-Activity Analysis
Sulforaphane Yield: Raw vs. Cooked
SCIENTIFIC DATA VISUALIZATION
Health Benefits & Sources
Why You Need It
- Cellular Defense: Supports the body’s natural ability to neutralize harmful toxins.
- Antioxidant Power: Helps reduce oxidative stress, which contributes to healthy aging.
- Inflammation Balance: Helps maintain a healthy inflammatory response in the body.
- Metabolic Support: Emerging research suggests a role in metabolic health.
Deep Dive
Isothiocyanates (ITCs) work by activating a pathway in your cells called the Nrf2 pathway. Imagine this pathway as a master switch that turns on your body's internal antioxidant defenses. When you eat foods rich in ITCs, you aren't just getting antioxidants; you are telling your body to produce its own.
A specific ITC called Sulforaphane (found in broccoli sprouts) is the star player here. Studies suggest it is one of the most potent natural activators of this detoxification system, helping your liver process and eliminate waste products more efficiently.
Natural Food Sources
The key to getting isothiocyanates is preparation. These compounds are formed when an enzyme (myrosinase) mixes with glucosinolates. This happens when the plant is damaged (chewed, chopped, or blended).
Top Sources: Broccoli sprouts (highest), Broccoli, Cabbage, Kale, Watercress, Arugula, Mustard greens, Radishes.
| Food | Amount | % DV (Est.) |
|---|---|---|
| Broccoli Sprouts | 1/2 cup | 200%+ |
| Watercress | 1 cup | 100% |
| Broccoli | 1 cup cooked | 80% |
| Kale | 1 cup raw | 60% |
| Mustard Greens | 1 cup cooked | 50% |
Supplementation
Food First: For general health, aim for 1-2 servings of these cruciferous vegetables daily.
Supplements: If you dislike the taste or cannot eat enough, look for "Glucoraphanin" or "Sulforaphane" supplements. Many are derived from broccoli sprout extract. Ensure the supplement contains the active enzyme or is stabilized to convert to the active form.
Top Food Sources
Frequently Asked Questions
Safety & Side Effects
Isothiocyanates are generally very safe when consumed through whole foods.
Who should be cautious?
- Thyroid Issues: In extremely high doses (usually via concentrated supplements), goitrogens can interfere with iodine uptake. If you have hypothyroidism, cook your cruciferous vegetables and consult your doctor before taking high-dose extracts.
- Blood Thinners: Some concentrated extracts may have mild blood-thinning effects.
- Digestion: Switching to a high-fiber, high-cruciferous diet suddenly may cause temporary gas or bloating. Introduce slowly.
Scientific References
- [1]Fahey, J. W., et al. (1997). 'Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens.' Proceedings of the National Academy of Sciences.
- [2]Houghton, C. A., et al. (2016). 'Sulforaphane: The 'phytochemical' of the future?' Biochemical Pharmacology.
- [3]National Cancer Institute. 'Isothiocyanates.' Antioxidants and Cancer Prevention.