DrFeb
Health Guide

Leucovorin

Leucovorin, also known as folinic acid, is a powerful B-vitamin derivative. Unlike standard folic acid, it bypasses specific metabolic steps in your body, making it a more active and readily usable form of folate. While it is a potent prescription medication used in cancer treatment and specific genetic conditions, it is also available as a dietary supplement for general health support. Think of it as a high-octane fuel for your cells, essential for DNA repair, red blood cell formation, and keeping your brain sharp. It plays a critical role in the methylation cycle, a fundamental process that impacts everything from your energy levels to your mood.
Evidence BasedDietary Supplement
Leucovorin
VERIFIED SOURCE

Bio-Activity Analysis

Folate Bioavailability by Form

SCIENTIFIC DATA VISUALIZATION

Y-Axis
Bioavailability (%)
Folate Type →

Health Benefits & Sources

Why You Need It

  • Reduces Homocysteine: Helps convert a potentially harmful amino acid (homocysteine) into methionine, supporting heart health.
  • Cellular Repair: Essential for creating DNA and RNA, which is crucial for healthy cell growth and repair.
  • Red Blood Cell Formation: Prevents megaloblastic anemia, ensuring your body transports oxygen efficiently for optimal energy.
  • Cognitive Support: Supports neurotransmitter synthesis, which can help maintain mental clarity and brain function.

Deep Dive

Leucovorin functions as a 'donor' for single-carbon units in your body, a process technically known as one-carbon metabolism. This is the engine room for creating genetic material (DNA) and managing chemical reactions. For the average person, ensuring adequate folate status (which Leucovorin supports) is vital. However, Leucovorin is particularly unique because it bypasses a genetic bottleneck (the MTHFR enzyme). If you have a variation in this gene, your body struggles to use standard folic acid. In these cases, Leucovorin provides the active folate your body desperately needs to function correctly.

Natural Food Sources

While Leucovorin is often taken as a supplement, the best way to support your body's folate levels naturally is by eating folate-rich whole foods. The body then converts this natural folate into active forms like Leucovorin.

FoodAmount (Raw)Folate Content (Approx % DV)
Beef Liver3 oz54%
Spinach1 cup15%
Asparagus4 spears17%
Brussels Sprouts1/2 cup12%
Avocado1/2 fruit10%
Broccoli1/2 cup7%

Supplementation

Dosage: There is no official RDA for Leucovorin as it is primarily a medical drug. For general health, standard Folic Acid (400-800 mcg) is usually recommended. If using a folinic acid (Leucovorin) supplement, typical doses range from 400 mcg to 5 mg daily, but this should be guided by a healthcare provider.

Who Should Take It:

  1. Individuals with MTHFR gene mutations (detected via genetic testing).
  2. People with malabsorption issues.
  3. Those undergoing specific medical treatments (under doctor supervision).

Top Food Sources

Beef Liver
3oz provides over 50% DV
Spinach
1 cup raw provides 15% DV
Asparagus
4 spears provide 17% DV
Avocado
1/2 fruit provides 10% DV
Broccoli
1/2 cup cooked provides 10% DV

Frequently Asked Questions

No. Folic acid is a synthetic, inactive form. Leucovorin (folinic acid) is an active form that your body can use immediately without needing to perform chemical conversions.
Yes! For 99% of the population, eating spinach, broccoli, and liver is the safest and most effective way to get the folate you need.
It acts as a 'rescue' agent. It helps healthy cells recover from the effects of chemotherapy drugs like 5-FU while the cancer cells are killed.
Some studies suggest that people with low folate respond better to antidepressants, and supplementing with active folate (like Leucovorin) may help, but it is not a primary treatment.

Safety & Side Effects

Safety & Interactions

WARNING: Chemical Nature Leucovorin is a potent chemical compound. While it is a vitamin derivative, it is powerful and must be used with respect.

  • Prescription Status: In high doses (used for cancer rescue therapy), it is a prescription drug. Do not self-medicate with high doses.

  • The 'Masking' Effect: Taking high doses of folate can hide a Vitamin B12 deficiency. This is dangerous because while the folate fixes the anemia, the B12 deficiency can continue to damage your nerves. Always ensure your B12 levels are adequate.

  • Drug Interactions:

    • 5-Fluorouracil (5-FU): Leucovorin is often used to enhance this chemotherapy drug. Taking them together is intended by doctors but dangerous without supervision.
    • Phenytoin (Dilantin): Folate can lower seizure threshold; Phenytoin can lower folate levels. Balance is key.

  • Kidney Issues: Use with caution if you have severe kidney impairment.

Bottom Line: If you are generally healthy and eat a balanced diet, you likely do not need Leucovorin supplements. Stick to natural folate from food.

Scientific References

  • [1]MTHFR Gene: A Comprehensive Review - National Institutes of Health (NIH)
  • [2]Leucovorin and 5-Fluorouracil in Colorectal Cancer - New England Journal of Medicine
  • [3]Folate and Vitamin B12: Functions and Clinical Importance - American Journal of Clinical Nutrition