Lysophosphatidic acid

Bio-Activity Analysis
LPA Levels in Common Dietary Sources
SCIENTIFIC DATA VISUALIZATION
Health Benefits & Sources
Why You Need It
- Supports Metabolic Health: Helps regulate glucose metabolism and insulin sensitivity.
- Promotes Skin Barrier Function: Essential for maintaining a healthy, hydrated skin barrier.
- Aids in Tissue Repair: Plays a signaling role in the wound-healing process.
- Modulates Pain Perception: Influences sensory neurons, potentially helping with discomfort.
Deep Dive
LPA functions by binding to specific receptors on the surface of your cells, triggering a cascade of internal signals. This mechanism is vital for cellular repair and regeneration. When it comes to metabolism, LPA signaling helps your body manage blood sugar levels more effectively. For your skin, it supports the production of lipids that keep moisture in and irritants out. While your body synthesizes LPA, dietary intake (mostly from fats) and specific supplements can help maintain optimal levels for these critical functions.
Supplementation
LPA is available as a dietary supplement, usually derived from safflower oil. It is typically taken for targeted goals like skin health or metabolic support. Dosages in studies often range from 1mg to 5mg daily, but it is crucial to follow the specific product label instructions. Consult a healthcare provider before starting, especially if you have existing health conditions.
Natural Food Sources
Unlike vitamins, LPA isn't listed on standard food charts. It is a phospholipid found in varying amounts in animal and plant tissues. You consume it by eating foods rich in healthy fats and phospholipids.
| Food | Amount | % DV |
|---|---|---|
| Soy Lecithin | ~100mg per tbsp | N/A |
| Egg Yolks | ~50mg per yolk | N/A |
| Beef Brain | High concentration | N/A |
| Safflower Oil | Trace amounts | N/A |
| Shellfish | Moderate | N/A |
Top Food Sources
Frequently Asked Questions
Safety & Side Effects
LPA is generally considered safe for consumption at recommended dosages. However, because it is a potent signaling molecule, there is theoretical concern regarding its role in cell proliferation. Caution is advised for individuals with a history of hormone-sensitive cancers, as LPA receptors are present on many cancer cells. Always consult a doctor before adding this supplement to your regimen. Mild digestive upset is the most common side effect.
Scientific References
- [1]Yanagida, K., et al. (2018). 'Lysophosphatidic acid receptors in the nervous system.' *Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids*.
- [2]Aikawa, S., et al. (2016). 'LPA regulates glucose metabolism and insulin sensitivity.' *Journal of Lipid Research*.
- [3]Pagès, C., et al. (2011). 'Lysophosphatidic acid signaling in human epidermis.' *Journal of Investigative Dermatology*.