Health Guide

Mangostin

Meet Mangostin (often called the 'Queen of Fruits' extract), a powerful natural compound found primarily in the rind of the mangosteen fruit. This vibrant tropical fruit, native to Southeast Asia, has been used for centuries in traditional medicine. Today, science is catching up, revealing Mangostin as a potent antioxidant and anti-inflammatory agent. It belongs to a group of compounds called xanthones, which are responsible for its impressive health benefits. Think of it as nature's sophisticated shield, helping your body combat oxidative stress and maintain cellular health.

Evidence BasedDietary Supplement

VERIFIED SOURCE

Bio-Activity Analysis

Antioxidant Potency Comparison (ORAC Value)

SCIENTIFIC DATA VISUALIZATION

Y-Axis

Antioxidant Units

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Health Benefits & Sources

Why You Need It

Potent Antioxidant Power: Fights free radicals that cause aging and cellular damage.
Supports a Healthy Inflammatory Response: Helps keep swelling down naturally.
Promotes Radiant Skin: Protects skin cells from UV damage and aging.
Boosts Immune Function: Supports the body's natural defenses.

Deep Dive

Mangostin works by neutralizing unstable molecules called free radicals. Imagine your cells as a clean house; free radicals are like dust and dirt trying to settle everywhere. Mangostin acts as a high-powered duster, cleaning them up before they can cause damage. Research indicates that Mangostin activates specific proteins in your body (like SIRT1 and AMPK) that regulate aging and metabolism. Furthermore, studies suggest it supports a healthy gut microbiome, which is the foundation of your immune system.

Natural Food Sources

While Mangostin is most concentrated in the fruit's rind, finding it naturally in your diet is delicious!

Food Source	Part Used	Mangostin Content
Mangosteen Fruit	Rind (Pericarp)	Very High
Mangosteen Fruit	Pulp	Low to None
Purple Mangosteen	Whole Fruit	High in Rind

Supplementation

Dosage: There is no official RDA for Mangostin. In clinical studies, doses typically range from 250mg to 500mg of standardized mangosteen extract daily.

Who should take it?

Individuals looking for natural anti-inflammatory support.
Those wanting to improve skin health and combat signs of aging.
People seeking antioxidant protection as part of a wellness routine.

Tip: If eating the fresh fruit, don't be afraid to consume the rind (often blended into juices), as that is where the magic lives!

Top Food Sources

Fresh Mangosteen

Eat the rind for maximum benefit

Mangosteen Juice

Ensure it includes the pericarp

Mangosteen Powder

Concentrated source

Dried Rind

Often used in teas

Xanthone Supplements

Standardized extract

Frequently Asked Questions

Yes, the rind is edible and contains the highest concentration of Mangostin. However, it is tough and bitter. It is often dried and ground or juiced.

For skin and inflammation, consistent daily use for 4-8 weeks is typically needed to notice changes.

Consult your doctor. While natural, high-dose extracts can potentially lower blood pressure further.

Mangostin is sold as a dietary supplement, not a drug. The FDA does not approve supplements for safety or efficacy, but they regulate manufacturing practices.

Safety & Side Effects

Safety Profile

Generally Recognized as Safe (GRAS): For most healthy adults, Mangostin derived from food sources or standard supplements is safe.

Potential Side Effects: High doses (above 800mg/day) may cause mild nausea or stomach upset.

CRITICAL Interactions: Mangostin may inhibit a specific liver enzyme (CYP3A4). This means it can affect how your body processes certain prescription medications, specifically blood thinners (like Warfarin) and certain blood pressure medications.

Caution: Pregnant or breastfeeding women should avoid concentrated extracts due to a lack of safety data.

Scientific References

[1]Chen, L. G., et al. (2008). Anti-inflammatory activity of mangostin derivatives.
[2]Obolsuwan, P., et al. (2019). Antioxidant and anti-aging properties of mangostin.
[3]Yang, H. L., et al. (2018). Immunomodulatory activity of Garcinia mangostana Linn.