Health Guide

Myristicin

Myristicin is a naturally occurring organic compound and essential oil found in plants, most notably nutmeg. Chemically, it is a phenylpropene, giving spices like nutmeg and parsley their distinct aromas. While used in small amounts for culinary flavoring, Myristicin has captured scientific interest for its psychoactive and neuroprotective potential. It acts as a mild hallucinogen in high doses and contains antioxidant properties that may protect brain cells. Understanding this compound is vital for spice lovers, as the line between a flavorful meal and a toxic dose is surprisingly thin.
Evidence BasedDietary Supplement
Myristicin
VERIFIED SOURCE

Bio-Activity Analysis

Myristicin: Safety vs. Dosage

SCIENTIFIC DATA VISUALIZATION

Y-Axis
Safety/Effect Level
Intake Level

Health Benefits & Sources

Why You Need It

  • Neuroprotection: May help protect neurons from oxidative stress.
  • Antioxidant Activity: Fights free radicals in the body.
  • Pest Control: Acts as a natural biopesticide (ingested in tiny amounts via food).

Deep Dive

Myristicin is a fascinating compound that walks a fine line between benefit and risk. Its primary value lies in its potential as a neuroprotective agent. Preliminary studies suggest that Myristicin may inhibit the enzyme responsible for breaking down acetylcholine, a neurotransmitter essential for memory and learning. This mechanism is similar to drugs used to treat Alzheimer's disease, though human research is lacking.

It also acts as a potent antioxidant, scavenging harmful free radicals that cause cellular aging. However, the most notable aspect of Myristicin is its psychoactive potential. In very high concentrations (far beyond culinary use), it converts in the body to MMDA, a compound similar to ecstasy. While this is generally considered a safety risk rather than a health benefit, it highlights the compound's ability to interact strongly with the brain.

Natural Food Sources

Myristicin is found in the essential oils of various spices and vegetables. It is most concentrated in nutmeg, but parsley and celery are also common sources.

Food SourceAmount (Estimate)Concentration
Nutmeg (Spice)High2-4% of essential oil
Parsley (Fresh)Low/MediumTrace amounts in oil
Celery (Seeds)Low/MediumTrace amounts in oil
Dill (Seed)LowTrace amounts

Supplementation

There are no standard supplements for Myristicin.

It is generally consumed as a flavoring agent in food or, rarely, in concentrated essential oil form for aromatherapy (never ingest pure essential oil without professional guidance). The FDA classifies nutmeg oil as 'Generally Recognized as Safe' (GRAS) only when used in very small amounts for flavoring. Consuming it in pill or concentrated form is dangerous.

Top Food Sources

Nutmeg (Ground)
1 tsp contains ~10mg active oil
Parsley (Fresh)
Safe in all culinary amounts
Celery Seeds
Common in spice blends
Dill Weed
Trace amounts
Black Pepper
Negligible amounts

Frequently Asked Questions

Yes, but it is not a 'safe' high. Consuming a large amount (5-15 grams) causes a deliriant state characterized by anxiety, hallucinations, and severe physical illness, not the euphoria of classic psychedelics.
No, though it was once rumored to be. Myristicin is chemically unrelated to THC. However, in high doses, it produces effects that some compare to a mix of LSD and alcohol.
Yes. You would have to eat an impossible amount of fresh parsley to feel toxic effects. The Myristicin content in fresh herbs is very low and safe.
No. Myristicin is a stable compound that survives heat. However, you typically use small amounts in cooking, keeping you well within the safety zone.

Safety & Side Effects

Safety Profile: Know Your Limits

Toxicity Warning: Myristicin is toxic in high doses. Consuming just 2 teaspoons to 2 tablespoons of ground nutmeg (which contains high levels of Myristicin) can induce severe intoxication.

Side Effects of Overdose:

  • Extreme nausea and vomiting
  • Severe dry mouth
  • Rapid heartbeat (tachycardia)
  • Agitation and hallucinations
  • Delirium (can last for days)

Who Should Avoid It:

  • Individuals with liver disease (Myristicin is metabolized by the liver).
  • People with a history of psychosis or seizures.
  • Pregnant or breastfeeding women (safety data is insufficient).

Interactions: It may interact with sedatives or drugs metabolized by the liver (CYP enzymes).

Scientific References

  • [1]Lee, B. K., & Yates, C. (1986). 'Myristicin in nutmeg toxicity.' *Journal of Analytical Toxicology*.
  • [2]Hallström, H., & Thuvander, A. (1997). 'Toxicological evaluation of myristicin.' *Food and Chemical Toxicology*.
  • [3]Truitt, E. B., et al. (1961). 'The pharmacology of myristicin.' *Psychopharmacologia*.