DrFeb
Health Guide

N-Acetyl-Tyrosine

N-Acetyl-Tyrosine (NAT) is a highly bioavailable form of the amino acid L-Tyrosine, a crucial building block for brain chemicals. While your body makes Tyrosine, high stress depletes it. NAT acts as a 'refill' for your neurotransmitters—specifically dopamine and norepinephrine—helping you stay sharp, focused, and resilient when the pressure is on. It is the non-jittery way to support mental clarity.
Evidence BasedDietary Supplement
N-Acetyl-Tyrosine
VERIFIED SOURCE

Bio-Activity Analysis

Tyrosine Absorption Comparison

SCIENTIFIC DATA VISUALIZATION

Y-Axis
Solubility / Bioavailability
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Health Benefits & Sources

Why You Need It

  • Cognitive Performance: Enhances memory and focus, particularly during stressful situations or sleep deprivation.
  • Mood Regulation: Provides the precursor to dopamine, supporting motivation and a positive outlook.
  • Stress Resilience: Replenishes neurotransmitters depleted by chronic stress, preventing mental burnout.
  • Metabolic Support: Essential for the synthesis of thyroid hormones which regulate metabolism.

Deep Dive

N-Acetyl-Tyrosine works by bypassing the rate-limiting step of standard Tyrosine absorption. The 'acetyl' group makes it more water-soluble. Once absorbed, your body converts it into L-Tyrosine, and then into L-DOPA, and finally into Dopamine. This pathway is vital for the 'executive functions' of your brain—planning, focus, and decision-making. Unlike stimulants that force energy out of your reserves, NAT simply ensures you have the raw materials available to function optimally.

Natural Food Sources

You can easily meet your daily Tyrosine needs through diet. Animal proteins are the most concentrated sources, but plant-based options are excellent too.

FoodAmountTyrosine Content
Turkey Breast3 oz~1.0g
Parmesan Cheese1 oz~0.8g
Pumpkin Seeds1/4 cup~0.5g
Soybeans1/2 cup~0.5g
Avocado1 medium~0.4g

Supplementation

NAT is usually taken in capsules or powder. It is best taken on an empty stomach (with water) to maximize absorption. It is often found in 'Nootropic' stacks combined with B-Vitamins (which help convert Tyrosine into Dopamine).

Top Food Sources

Beef (Ground, 85% lean)
1.1g per 3oz serving
Chicken Breast
1.0g per 3oz serving
Peanuts
0.5g per 1/4 cup
Eggs
0.5g per 2 large eggs
Spirulina
3.5g per 1oz (dried)

Frequently Asked Questions

NAT is more water-soluble, which theoretically allows for better absorption. However, some studies suggest the acetyl group may be removed before entering the bloodstream. Many users report fewer stomach issues with NAT.
No. Tyrosine is not a stimulant. It provides the fuel for focus, but does not artificially speed up your heart rate like caffeine does.
Yes, but some experts recommend cycling it (e.g., taking breaks on weekends) to prevent your body from building a tolerance to its effects.
Indirectly. By supporting thyroid function and reducing 'stress eating' due to better mood regulation, it can assist in weight management, but it is not a direct fat burner.

Safety & Side Effects

Generally safe for healthy adults. However, individuals with Graves' disease (hyperthyroidism) should avoid it, as Tyrosine is a precursor to thyroid hormones. It may interact with MAOIs (antidepressants), potentially causing a hypertensive crisis (dangerously high blood pressure). If you are on medication, consult your doctor.

Scientific References

  • [1]Jongkees, B. J., et al. (2015). Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands.
  • [2]Deijen, J. B., & Orlebeke, J. F. (1994). Effect of tyrosine on cognitive function and blood pressure under stress.
  • [3]National Institutes of Health (NIH) - Office of Dietary Supplements: Tyrosine Fact Sheet for Health Professionals.