DrFeb
Health Guide

N-phenylacetyl-L-Prolylglycine ethyl ester

N-phenylacetyl-L-Prolylglycine ethyl ester, commonly known as Semax, is a synthetic neuropeptide derived from the ACTH hormone fragment. It is classified as a nootropic because it enhances cognitive function, memory, and attention without the jittery side effects of stimulants. It functions by increasing Brain-Derived Neurotrophic Factor (BDNF) and protecting neurons from damage.
Evidence BasedDietary Supplement
N-phenylacetyl-L-Prolylglycine ethyl ester
VERIFIED SOURCE

Bio-Activity Analysis

Semax Bioavailability

SCIENTIFIC DATA VISUALIZATION

Y-Axis
Absorption Rate
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Health Benefits & Sources

Why You Need It

  • Cognitive Enhancement: Improves focus, memory, and mental energy.
  • Neuroprotection: Shields the brain from oxidative stress and hypoxia.
  • Mood Regulation: Modulates dopamine and serotonin levels for better stress resilience.

Deep Dive

This peptide works by mimicking the body's natural stress-response hormones in a controlled, non-stressful way. It increases the expression of BDNF, a protein essential for the growth of new neurons and synapses. It also prevents the breakdown of enkephalins, natural opioids that improve mood and pain regulation.

Natural Food Sources

Important: This specific compound is synthetic and is not found in food. It is manufactured in laboratories for medical and nootropic use.

Supplementation

To support natural peptide health, consume foods rich in Proline and Glycine (bone broth, gelatin) and Tyrosine (meat, dairy, nuts). Semax is typically taken as a nasal spray (0.1% to 1% solution) or sublingual drops.

Top Food Sources

Bone Broth
Rich in Glycine/Proline (Precursors)
Grass-fed Beef
Rich in Tyrosine (Precursor)
Eggs
Rich in Choline & Amino Acids
Pumpkin Seeds
Rich in Tyrosine
Dairy Products
Rich in Proline

Frequently Asked Questions

Yes, it is legal in the USA and many other countries as a research chemical and dietary supplement, but not FDA-approved for medical treatment.
When taken as a nasal spray, it is usually tasteless, though some users report a slight chemical sensation in the back of the throat.
The cognitive effects typically last 3 to 4 hours, though the neuroprotective benefits may last longer.
Yes, it stacks well with caffeine, often smoothing out the 'jitters' and providing a focused energy.

Safety & Side Effects

Generally considered safe at recommended dosages. Side effects are rare but may include nausea or dry mouth. Do not use without medical advice if you have a history of hormone-sensitive conditions or are taking psychoactive medications.

Scientific References

  • [1]Ashmarin, I. P., et al. (1997). 'Comparative study of the effects of Semax and ACTH(4-10) on memory processes.'
  • [2]Khvan, M. B., et al. (2019). 'Semax as a neuroprotective agent in ischemic stroke.'
  • [3]National Center for Biotechnology Information (NCBI). 'Semax: A synthetic peptide with nootropic properties.'