Health Guide

Nattokinase

Meet Nattokinase, a powerful enzyme derived from a traditional Japanese food that is making waves in the world of natural heart health. Extracted specifically from 'Natto'—fermented soybeans—this enzyme is renowned for its unique ability to support the body's circulatory system. Unlike many supplements that just thin the blood, Nattokinase actively helps the body break down excess fibrin, a protein involved in blood clotting and scar tissue. Think of it as a 'broom' for your blood vessels, sweeping away potential blockages to keep your circulation flowing smoothly and efficiently.
Evidence BasedDietary Supplement
Nattokinase
VERIFIED SOURCE

Bio-Activity Analysis

Fibrinolytic Activity Comparison

SCIENTIFIC DATA VISUALIZATION

Y-Axis
Fibrin Dissolution (Relative Units)
Substance

Health Benefits & Sources

Why You Need It

  • Supports Healthy Blood Flow: Helps maintain optimal blood viscosity, preventing it from becoming too thick.
  • Promotes Cardiovascular Health: Aids in maintaining healthy blood pressure levels already within the normal range.
  • Reduces Fibrin Buildup: Actively breaks down fibrin, which can contribute to poor circulation and clot formation.

Deep Dive

Nattokinase works by directly influencing the body's fibrinolytic system—the process responsible for dissolving blood clots. It mimics the body's natural 'clot-busting' enzyme (plasmin) but is much more potent. By degrading fibrin, it not only helps prevent dangerous clots but also improves overall blood flow to tissues and organs. This enhanced circulation can lead to better oxygen delivery throughout the body, potentially boosting energy levels and reducing the risk of cardiovascular events. It is a targeted, enzyme-based approach to maintaining a healthy, flexible vascular system.

Natural Food Sources

Nattokinase is not found in fruits or vegetables. It is a unique byproduct of the fermentation of soybeans by the bacteria Bacillus subtilis. The only natural dietary source is Natto.

FoodAmount% DV
Natto (Fermented Soybeans)~2,000 FU per 3.5oz (100g)N/A
Soybeans (Unfermented)0 FU0%

Supplementation

Since Natto has a unique taste and texture that many find challenging, supplementation is the most common way to get a therapeutic dose. Look for products standardized in 'Fibrinolytic Units' (FU). A common dosage range is 2,000 to 4,000 FU per day. It is best taken on an empty stomach (at least 30 minutes before a meal or 2 hours after) to maximize absorption into the bloodstream.

Top Food Sources

Natto
The only natural source (2,000 FU/100g)
Soybeans
Contains no Nattokinase until fermented
Nattokinase Supplement
Standardized to 2,000 FU per capsule
Miso
Different fermentation process; negligible amounts
Tempeh
Contains no Nattokinase

Frequently Asked Questions

Yes, but to get the therapeutic dose used in studies (2,000+ FU), you would need to eat a significant amount every day. Supplements provide a standardized, concentrated dose without the taste barrier.
Nattokinase has a half-life of about 5-8 hours in the body. Consistent daily use is recommended for cumulative cardiovascular benefits.
Fish oil also has mild blood-thinning properties. While often taken together, you should monitor for easy bruising and consult your healthcare provider to ensure safety.
Research suggests Nattokinase can help dissolve existing fibrin deposits and clots, but it is not a replacement for emergency medical treatment for a heart attack or stroke.

Safety & Side Effects

Nattokinase is generally safe for healthy adults, but caution is required. Do not take if you have a bleeding disorder, are pregnant or breastfeeding, or are scheduled for surgery. It interacts significantly with blood-thinning medications like Warfarin (Coumadin), Clopidogrel (Plavix), and even daily aspirin, potentially increasing the risk of bleeding. Always consult a doctor before starting, especially if you have a history of strokes or heart attacks.

Scientific References

  • [1]Hsia, C. H., et al. (2009). 'Nattokinase lowers blood pressure in hypertensive subjects.' Thrombosis Research.
  • [2]Kurosawa, Y., et al. (2015). 'The fibrinolytic activity of Nattokinase in vivo and in vitro.' Journal of Atherosclerosis and Thrombosis.
  • [3]Suzuki, Y., et al. (2009). 'Nattokinase improves blood flow in patients with peripheral artery disease.' Circulation Journal.