Nitrogen Dioxide

Bio-Activity Analysis
Nitric Oxide Bioavailability: Food vs. Supplement
SCIENTIFIC DATA VISUALIZATION
Health Benefits & Sources
Why You Need It
- Boosts Exercise Performance: By increasing blood flow, it delivers more oxygen to working muscles, boosting stamina and helping you push harder.
- Supports Heart Health: It helps maintain flexible arteries and healthy blood pressure levels, reducing strain on your cardiovascular system.
- Enhances Nutrient Delivery: Better circulation means your body can shuttle vitamins and minerals to where they are needed most for recovery and repair.
Deep Dive
Nitrogen Dioxide (specifically the molecule Nitric Oxide) acts as a signaling molecule. As we age, our natural production declines. When you consume foods rich in nitrates (the precursor), your mouth bacteria convert them into Nitric Oxide. This molecule tells the smooth muscles lining your blood vessels to relax. The result? Wider vessels, lower resistance, and a 'pump' effect that benefits both your heart and your muscles. Unlike stimulants, this works by optimizing your body's existing plumbing.
Natural Food Sources
Nature is the best pharmacy for Nitric Oxide. The key is consuming nitrate-rich vegetables. Here are the top sources:
| Food | Amount | % DV (Est. Nitrate) |
|---|---|---|
| Beetroot | 1 cup (136g) | High |
| Arugula | 1 cup (20g) | Very High |
| Spinach | 1 cup (30g) | High |
| Rhubarb | 1 cup (122g) | High |
| Lettuce | 1 cup (36g) | Medium |
Supplementation
Best Form: L-Citrulline (converted to Arginine, then NO) is often more effective than straight L-Arginine. Who should use it: Athletes looking for a pump, or older adults seeking circulatory support. Dosage: Typical pre-workout doses range from 3g to 6g of L-Citrulline. However, eating beets 2 hours before exercise is a potent natural alternative.
Top Food Sources
Frequently Asked Questions
Safety & Side Effects
Safety & Side Effects
Safety: Generally recognized as safe (GRAS) when consumed via food.
Supplement Side Effects: High doses of NO boosters can cause:
- Stomach upset or diarrhea.
- Low Blood Pressure: Dizziness or lightheadedness.
- Headaches: Due to vessel dilation.
Interactions: CRITICAL - Do not take Nitric Oxide supplements if you are taking prescription nitrates (for chest pain) or PDE-5 inhibitors (like Viagra/Cialis). Combining these can cause a dangerous, sudden drop in blood pressure.
Scientific References
- [1]Jones, A. M., et al. (2018). 'Dietary Nitrate and Physical Performance.' *Journal of Applied Physiology*.
- [2]Hord, N. G. (2011). 'Dietary Nitrates, Nitrites, and Cardiovascular Health.' *The American Journal of Clinical Nutrition*.
- [3]Bondonno, C. P., et al. (2012). 'Flavonoid-rich apples and endothelial function.' *The American Journal of Clinical Nutrition*.