Oxaloacetate

Why You Need It

• Cellular Energy Production: OAA is the starting point of the Krebs cycle. Adequate levels ensure your mitochondria can efficiently burn glucose and fats for fuel.
• Cognitive Support: By fueling brain cells and acting as a neuroprotective agent, OAA may help maintain focus and mental sharpness.
• Blood Sugar Regulation: It plays a role in gluconeogenesis (making new glucose), helping stabilize blood sugar levels during fasting.
• Anti-Aging Potential: Recent research suggests OAA helps rejuvenate aged stem cells, supporting overall vitality.

Deep Dive

Oxaloacetate is unique because it is the very first molecule produced when you eat and start the process of cellular respiration. Without OAA, your cellular engine stalls. This is why it's often linked to combatting 'brain fog' and fatigue. Unlike stimulants that force energy out of your body, OAA supports the natural production of energy. It is also a precursor to aspartic acid, an amino acid that supports the immune system and hormone production.

Natural Food Sources

Because Oxaloacetate is an intermediate in the metabolic cycle, it is found in low concentrations in most foods. However, you can obtain its precursors (Malic Acid and Aspartic Acid) easily from whole foods. Food first is always the best strategy.

Supplementation

Since OAA is unstable in the stomach, dietary supplements typically use Calcium Pyruvate or D-ribose to support the pathway, or stabilized proprietary blends.

• Standard Dosage: If taking a supplement (usually as Pyruvate), studies suggest 5–10 grams daily for athletic performance.
• Who Should Take It: Individuals experiencing chronic fatigue, those over 40 looking to support metabolic health, or athletes seeking endurance support.
• Best Time: Take with a meal to aid absorption.