Health Guide

Oxedrine

Oxedrine (also known as p-synephrine) is a natural bioactive compound found primarily in the peel and pith of citrus fruits like bitter orange. Often referred to as 'nature's caffeine,' it is structurally similar to ephedrine but acts differently in the body. It has been used for centuries in traditional medicine and is currently one of the most popular dietary supplements for weight management and energy. Unlike stimulants that spike cortisol, Oxedrine selectively activates adrenergic receptors to boost metabolic rate and lipolysis (fat burning) without the jittery crash often associated with high-dose caffeine.
Evidence BasedDietary Supplement
Oxedrine
VERIFIED SOURCE

Bio-Activity Analysis

Metabolic Rate Increase (Thermogenesis)

SCIENTIFIC DATA VISUALIZATION

Y-Axis
Increase in Energy Expenditure (%)
Compound

Health Benefits & Sources

Why You Need It

  • Metabolic Boost: Increases resting energy expenditure, helping you burn more calories throughout the day.
  • Lipolysis Support: Helps mobilize fatty acids from adipose tissue, making them available to be burned as fuel.
  • Appetite Regulation: May help suppress appetite signals, making it easier to adhere to a calorie deficit.
  • Mild Energy Lift: Provides a clean, non-jittery stimulation that enhances focus and alertness.

Deep Dive

Oxedrine works by binding to beta-adrenergic receptors in the body. Think of these receptors as switches; when flipped, they signal your body to break down fat stores and increase heat production (thermogenesis). Clinical studies suggest that oxedrine can increase metabolic rate by roughly 5-7% without significantly raising heart rate or blood pressure in healthy individuals. It is often stacked with caffeine because it works via a slightly different pathway, offering a synergistic effect that extends energy levels and fat-burning potential.

Natural Food Sources

Oxedrine is not found in standard multi-vitamins; it must be consumed via specific citrus fruits or supplements. The highest concentrations are found in the peel and white pith (albedo).

Food SourcePreparationOxedrine Content
Bitter Orange (Seville)Raw/WholeHigh
Citrus PeelDried/ZestedModerate to High
Mandarin OrangeRawLow
Lemon/Lime PeelZestedLow

Supplementation

Dosage: The standard clinical dose ranges from 30mg to 60mg per day. Timing: Take 30–60 minutes before exercise or meals for best results. Who Should Use It: Ideal for healthy adults looking to support weight loss efforts or improve workout energy. It is particularly popular in 'fat burner' formulations.

Top Food Sources

Seville Orange (Bitter Orange)
Peel contains ~6% Oxedrine by weight
Yuzu Fruit
Japanese citrus with bioactive peels
Mandarin Peel
Great for zesting into foods
Citrus Aurantium Extract
Standardized supplement form
Lemon Zest
Adds flavor + trace benefits

Frequently Asked Questions

No. While chemically related, Oxedrine (p-synephrine) is much milder. It does not carry the same high risk of stroke or heart attack that led to the ban of Ephedrine in many countries.
Naturally, no. Oxedrine is the active compound in bitter orange. However, it is often sold in 'stacked' supplements that contain caffeine for a synergistic effect.
Generally no for standard tests. However, because it is structurally similar to banned stimulants, professional athletes should check with their specific governing body (WADA/USADA) before use.
Oxedrine usually takes 30 to 60 minutes to take effect. It is fat-soluble, so taking it on an empty stomach may speed up absorption.

Safety & Side Effects

Safety Profile

Oxedrine is generally recognized as safe (GRAS) for healthy adults at recommended dosages.

Potential Side Effects:

  • Mild increase in heart rate.
  • Jitters (rare, usually occurs at high doses >80mg).
  • Increased body temperature.

Who Should Avoid It:

  • Heart Conditions: Individuals with arrhythmias, hypertension, or history of heart disease.
  • Pregnancy/Breastfeeding: Not recommended.
  • Medication Interactions: Avoid if taking MAO inhibitors or stimulant medications. Consult a doctor if you take prescription drugs for blood pressure.

Scientific References

  • [1]Stohs, S. J., et al. (2012). 'A review of the human clinical studies involving Citrus aurantium (bitter orange) extract.' *Food and Chemical Toxicology*.
  • [2]Gougeon, R., et al. (2005). 'Effect of p-synephrine on resting metabolic rate and substrate utilization.' *Journal of the American College of Nutrition*.
  • [3]Penzak, S. R., et al. (2001). 'Bitter orange (Citrus aurantium) as a dietary supplement.' *Annals of Pharmacotherapy*.