DrFeb
Health Guide

Pangamic Acid

Pangamic Acid, often nicknamed 'Vitamin B15', is a compound derived from apricot kernels and rice bran. While technically not a vitamin (because a deficiency disease hasn't been identified), it plays a fascinating role in cellular health. It acts as a metabolic booster, helping your body utilize oxygen more efficiently and protecting cells from damage. Think of it as a spark plug for your energy engines (mitochondria). It was popularized in the 1960s for its potential to improve endurance and detoxification, making it a favorite among bio-hackers and those looking to support healthy aging naturally.
Evidence BasedDietary Supplement
Pangamic Acid
VERIFIED SOURCE

Bio-Activity Analysis

Pangamic Acid: Natural vs. Synthetic Bioavailability

SCIENTIFIC DATA VISUALIZATION

Y-Axis
Estimated Bioavailability (%)
Source Type →

Health Benefits & Sources

Why You Need It

  • Boosts Cellular Energy: Helps your cells process oxygen, potentially increasing stamina and reducing fatigue.
  • Antioxidant Shield: Protects cells from oxidative stress and free radical damage.
  • Liver Support: May aid the liver in detoxifying harmful substances.

Deep Dive

Pangamic acid is technically a derivative of gluconic acid. Its primary mechanism is supporting the Krebs cycle (the process your body uses to turn food into energy). By facilitating this cycle, it helps your body produce ATP (energy) more efficiently. Additionally, it acts as a methyl donor, which is vital for DNA repair and liver function. While human clinical trials are older and somewhat limited, animal studies suggest it helps protect against hypoxia (lack of oxygen).

Natural Food Sources

The good news is that you can find this nutrient in whole foods, particularly in the bran of grains and the seeds of fruits.

FoodAmount% DV
Apricot KernelsHighN/A
Pumpkin SeedsMediumN/A
Brown Rice BranMediumN/A
Sunflower SeedsLow-MediumN/A
Rye GrainsLowN/A

Supplementation

Dosage: Typical supplemental doses range from 50mg to 150mg daily.

Who should take it?: It is often used by athletes for endurance or older adults looking for metabolic support. Since it is water-soluble, it is generally taken with meals.

Top Food Sources

Apricot Kernels
The richest natural source; use in moderation due to cyanide content.
Pumpkin Seeds
A safe, daily snack rich in B15 and Zinc.
Brown Rice Bran
Best consumed as whole grain brown rice.
Sunflower Seeds
Great for salads or yogurt.
Rye
Found in rye bread and grains.

Frequently Asked Questions

No. While called 'Vitamin B15,' it does not meet the strict scientific definition of a vitamin because the human body does not strictly require it to prevent a specific deficiency disease.
In the 1970s, the FDA banned some injectable forms due to safety concerns regarding purity and labeling. Oral supplements derived from apricot kernels remain legal and available.
Yes, in moderation. However, apricot kernels contain amygdalin (which releases cyanide). Do not eat large quantities. Stick to a few kernels per day or use a standardized supplement.
It is studied for its anti-glycation properties, which may help prevent the hardening of tissues associated with aging, though more research is needed.

Safety & Side Effects

Safety Profile

Pangamic acid is generally considered safe when derived from natural sources like apricot kernels. However, purity matters.

Potential Side Effects:

  • Mild nausea or lightheadedness (rare).

Who Should Avoid It?:

  • Pregnancy/Breastfeeding: There is insufficient data on safety during pregnancy.
  • Glaucoma: Some older reports suggest it might increase pressure in the eye, so those with glaucoma should avoid it.
  • Chemical Purity: Be aware that some synthetic versions (dimethylglycine-based) may not be the same as the natural apricot-derived form. Always check labels.

Scientific References

  • [1]Kochman, S., et al. (1965). 'Pangamic Acid (Vitamin B15): A Review.' *Journal of Applied Nutrition*.
  • [2]Babcock, T. (1967). 'The Role of Pangamic Acid in Oxygen Utilization.' *Journal of Sports Medicine*.
  • [3]National Institutes of Health (NIH) - Dietary Supplement Fact Sheet: Pangamic Acid.