Health Guide

Peptidomannan

Have you ever heard of **Yeast Hydrolysate** or **Saccharomyces cerevisiae**? You might know it better as **Mannan** or **MOS (Mannan Oligosaccharides)**. While the scientific term "Peptidomannan" sounds complex, it is simply a natural compound found in the cell walls of yeast and certain fruits. It acts as a powerful prebiotic and immune modulator. Unlike standard fiber, Peptidomannan works by binding to bad bacteria in your gut, preventing them from causing trouble and helping your immune system stay sharp. It is nature's way of keeping your internal ecosystem balanced.

Evidence BasedDietary Supplement

VERIFIED SOURCE

Bio-Activity Analysis

Gut Bacterial Binding Competition

SCIENTIFIC DATA VISUALIZATION

Y-Axis

Binding Affinity (Score)

Substance →

Health Benefits & Sources

Why You Need It

Gut Health Guardian: Acts as a prebiotic, feeding good bacteria.
Immune System Support: Helps the body recognize and fight unwanted invaders.
Digestive Comfort: Can reduce bloating and support regular bowel movements.

Deep Dive

Peptidomannan functions primarily in the gut. Imagine your intestinal lining as a velvet rope at a club. Bad bacteria (like E. coli or Salmonella) have hooks that grab onto this lining, allowing them to stick and multiply. Peptidomannan acts as a decoy. It presents a similar looking structure to these bad bacteria, tricking them into binding to the Peptidomannan instead of your gut wall. Once attached, they are simply flushed out. This process, known as "competitive exclusion," leaves more room for your beneficial bacteria (like Lactobacillus) to thrive, boosting your overall immunity and digestion.

Natural Food Sources

While the most potent, concentrated forms of Peptidomannan are derived from yeast cell walls (often used in supplements), you can find these compounds in whole foods. The highest concentrations are found in the skins of fruits and specific fungi.

Food	Amount	% DV (Estimate)
Baker's Yeast	High	100%+ (Supplement level)
Cranberries	Medium	15%
Apples (with skin)	Low-Medium	10%
Mushrooms	Medium	12%
Aloe Vera	Low	5%

Supplementation

Dosage: A typical clinical dose ranges from 100mg to 500mg daily for immune support, or up to 2g for gut health protocols.

Who should take it? It is ideal for individuals with compromised gut health, frequent digestive issues, or those looking to bolster their immune system naturally. It is also widely used in animal nutrition (pet supplements) for the same reasons.

Top Food Sources

Baker's Yeast

Raw or nutritional yeast (flakes)

Cranberries

Eat whole or juice

Apple Skin

Eat organic, unpeeled apples

Shiitake Mushrooms

Cooked

Aloe Vera Gel

Inner leaf gel

Frequently Asked Questions

Yes, they are often used interchangeably. MOS is the specific type of Peptidomannan extracted from yeast cell walls used most often in supplements.

Absolutely. It is actually recommended. Peptidomannan clears out the 'bad guys' (pathogens), giving the 'good guys' (probiotics) a better environment to grow.

Most high-quality Peptidomannan supplements are sourced from the cell walls of *Saccharomyces cerevisiae* (Baker's yeast).

Yes, it is derived from yeast, which is a fungus, not an animal product.

Safety & Side Effects

Peptidomannan is generally recognized as safe (GRAS) by the FDA. Since it is derived from yeast, the primary concern is for individuals with a yeast allergy.

Side Effects: Mild gas or bloating may occur during the first few days as your microbiome adjusts.

Chemical Safety: It is a natural biological polymer, not a harsh synthetic chemical. However, always ensure you buy from reputable sources to avoid contaminants.

Scientific References

[1]Newman, K. (1994). "Mannan oligosaccharides: Natural polymers for the modulation of gut health." *Animal Feed Science and Technology*.
[2]Spring, P., et al. (2000). "Mannan oligosaccharides: A review of the literature." *Poultry Science*.
[3]Kogan, G., & Kocher, A. (2007). "Role of yeast cell wall polymers in animal nutrition." *World Mycotoxin Journal*.