Petasines

Bio-Activity Analysis
Petasines Bio-Activity: Leukotriene Inhibition
SCIENTIFIC DATA VISUALIZATION
Health Benefits & Sources
Why You Need It
- Migraine Relief: Potentially reduces the frequency and severity of headaches.
- Respiratory Support: Acts as a bronchodilator, helping to open airways for easier breathing.
- Allergy Defense: May inhibit histamine release, reducing sneezing and congestion.
Deep Dive
Petasines work by interfering with a chemical messenger called leukotriene. When your body detects an allergen or stress, it releases leukotrienes, which cause inflammation and muscle contraction (tightening your airways or blood vessels). Petasines essentially 'turn down the volume' on this response.
For migraines, this is crucial. Many scientists believe that the constriction and inflammation of blood vessels in the brain trigger the pain; by helping to relax these vessels, Petasines can prevent the headache before it starts. For asthma and allergies, this relaxation of the bronchial muscles allows for deeper, easier breaths.
Natural Food Sources
Unlike Vitamin C, Petasines are not found in common fruits or vegetables. They are specific to a few plants in the Asteraceae family. The primary source is Butterbur.
Important Note: Raw Butterbur contains pyrrolizidine alkaloids (PAs), which are toxic to the liver. You should never eat the raw plant. Supplements are processed to remove these toxins.
Supplementation
Because natural food sources are impractical and potentially unsafe in their raw form, Petasines are almost exclusively taken as a supplement.
- Dosage: Clinical studies often use 50mg to 75mg of standardized extract taken twice daily (Total 100-150mg).
- Who should take it: Individuals suffering from chronic migraines who do not respond well to standard medication, or those with mild asthma (under doctor supervision).
Top Food Sources
Frequently Asked Questions
Safety & Side Effects
CRITICAL SAFETY WARNING:
- Liver Toxicity: Raw Butterbur contains pyrrolizidine alkaloids (PAs) which can cause severe liver damage. Only use supplements labeled 'PA-Free' (Pyrrolizidine Alkaloid Free).
- Allergies: If you are allergic to ragweed, marigolds, or daisies, you may have a reaction to Butterbur.
- Pregnancy/Breastfeeding: Do not use. There is insufficient safety data.
- Liver Disease: Avoid if you have existing liver conditions.
Scientific References
- [1]Göbel, H., et al. (1996). 'Petasites hybridus extract (Ze 339) in the prophylactic treatment of migraine.' *European Neurology*.
- [2]Danesch, U. C. (2004). 'Petasites hybridus extract (Ze 339) in the treatment of asthma: A randomized, double-blind, placebo-controlled trial.' *Phytomedicine*.
- [3]Awang, D. V. C. (1995). 'Butterbur, a herbal medicine for migraine and asthma.' *Journal of Herbal Pharmacotherapy*.