Phenethyl isothiocyanate

Bio-Activity Analysis
PEITC Bioavailability: Food vs. Supplement
SCIENTIFIC DATA VISUALIZATION
Health Benefits & Sources
Why You Need It
- Cellular Defense: It helps protect your cells from oxidative stress and damage.
- Detoxification Support: It activates enzymes in the liver that help neutralize and eliminate toxins.
- Anti-Inflammatory: It may help lower markers of inflammation in the body.
- Metabolic Health: Early research suggests it supports healthy metabolism and weight management.
Deep Dive
PEITC works by triggering a biological process called the Nrf2 pathway. Think of Nrf2 as a master switch in your cells that turns on your body's natural antioxidant defenses. When you consume PEITC, this switch is flipped, prompting your body to produce more enzymes that fight off free radicals and repair cellular damage.
Furthermore, PEITC is unique because it interacts with specific proteins that regulate cell life and death. It encourages damaged cells to undergo 'apoptosis' (programmed cell death), which is essentially your body's way of removing potentially harmful cells before they can multiply. This makes it a key player in cancer prevention research, particularly for lung and colorectal health.
Natural Food Sources
PEITC is not found in synthetic foods; it must be derived from plants. The precursor compound, glucosinolate, is converted into PEITC when the plant cell walls are broken (chewing or chopping).
| Food | Amount | % DV | |---|---|---| | Watercress | 1 Cup (Raw) | Very High | | Arugula | 1 Cup (Raw) | High | | Radishes | 1 Cup | Moderate | | Bok Choy | 1 Cup (Cooked) | Moderate | | Broccoli | 1 Cup (Cooked) | Low-Moderate |
Supplementation
Because PEITC is sensitive to heat and cooking methods can reduce its potency, many people choose to supplement to ensure consistent intake.
- Dosage: There is no official RDA. Supplement studies often use doses ranging from 10mg to 60mg per day.
- Who Should Take It: Individuals looking for extra antioxidant support, those with a family history of certain cancers (always consult a doctor), or people who struggle to eat cruciferous vegetables daily.
- Best Form: Look for supplements derived from watercress extract or broccoli sprout extract.
Top Food Sources
Frequently Asked Questions
Safety & Side Effects
Safety & Side Effects
PEITC is generally considered safe when consumed in food amounts. However, concentrated supplements require caution.
- Gastrointestinal Distress: High doses may cause stomach upset, nausea, or gas.
- Blood Thinning: PEITC may have mild anticoagulant effects. If you are on blood thinners (like Warfarin) or have a bleeding disorder, consult your doctor.
- Thyroid Function: Like other cruciferous compounds, very high doses could interfere with iodine uptake in the thyroid. If you have hypothyroidism, monitor your intake.
Warning: Do not take PEITC supplements if you are pregnant or breastfeeding due to a lack of safety data.
Scientific References
- [1]Lin, H. J., et al. (2019). 'Phenethyl isothiocyanate inhibits prostate cancer progression'. *Oncology Reports*.
- [2]Conaway, C. C., et al. (2002). 'Phenethyl isothiocyanate and cancer prevention'. *Journal of Cellular Biochemistry*.
- [3]American Institute for Cancer Research (AICR). 'Glucosinolates and Cancer Prevention'.