Phosphotidylethanolamine

Bio-Activity Analysis
Bioavailability: Food vs. Supplement
SCIENTIFIC DATA VISUALIZATION
Health Benefits & Sources
Why You Need It
- Cell Membrane Health: PE comprises up to 50% of your cell membranes, ensuring cells stay flexible and functional.
- Brain Function: It is a precursor to phosphatidylcholine, which supports memory and cognitive processing.
- Liver Support: Helps transport fats out of the liver, preventing fat accumulation.
- Exercise Recovery: May help reduce muscle fatigue and improve endurance.
Deep Dive
Your body naturally produces Phosphatidylethanolamine, but it is also found in the foods you eat. Its primary job is structural; without sufficient PE, your cell walls become rigid and fragile. However, its most exciting role is conversion. Through a process called the 'Kennedy Pathway,' your body converts PE into Phosphatidylcholine (PC). PC is critical for producing acetylcholine, a neurotransmitter responsible for focus and memory. By ensuring you have enough dietary PE, you are supporting this vital metabolic pathway naturally.
Natural Food Sources
PE is found in high concentrations in organ meats and specific plant foods. It is often consumed as part of whole food fats.
| Food | Amount | % DV |
|---|---|---|
| Beef Liver | 300mg per 3oz | ~40% |
| Soybeans (Cooked) | 200mg per cup | ~25% |
| Chicken Breast | 150mg per 3oz | ~20% |
| Eggs (Yolk) | 100mg per large egg | ~15% |
| Peanuts | 80mg per 1/4 cup | ~10% |
Supplementation
While whole foods are best, PE is available as a supplement, often derived from soy lecithin. It is fat-soluble, so take it with a meal containing fat for best absorption. It is generally used to support cognitive health or liver function, but you should always consult a doctor before adding a concentrated phospholipid supplement to your regimen.
Top Food Sources
Frequently Asked Questions
Safety & Side Effects
Safety & Side Effects
Phosphatidylethanolamine is generally recognized as safe (GRAS) when consumed via food.
Potential Side Effects (Supplements):
- Mild digestive upset or diarrhea (due to the fat content).
- Nausea if taken on an empty stomach.
Who Should Avoid It:
- Histamine Intolerance: Some PE supplements (especially soy-derived) can be high in histamines. If you react to fermented foods, proceed with caution.
- Phosphorus Sensitivity: Individuals with severe kidney disease may need to monitor phosphorus intake, though dietary amounts are usually safe.
- Pregnancy: There is insufficient data on high-dose supplementation; stick to dietary sources.
Scientific References
- [1]Gibellini, F., & Smith, T. K. (2010). The Kennedy pathway—De novo synthesis of phosphatidylethanolamine and phosphatidylcholine. IUBMB Life.
- [2]Li, Z., & Vance, D. E. (2008). Phosphatidylcholine and choline homeostasis. Journal of Lipid Research.
- [3]Zeisel, S. H. (2012). Choline: Critical Role during Fetal Development and Dietary Requirements in Adults. Annual Review of Nutrition.