DrFeb
Health Guide

Picamilon

Picamilon (nicotinoyl-GABA) is a synthetic compound created by combining **niacin (Vitamin B3)** with **GABA** (a calming brain chemical). Unlike naturally occurring nutrients found in food, Picamilon is created in a lab to cross the blood-brain barrier more effectively. Once inside the brain, it breaks down into its components, potentially boosting blood flow and promoting relaxation. It is often used to support focus, mood, and stress relief.
Evidence BasedDietary Supplement
Picamilon
VERIFIED SOURCE

Bio-Activity Analysis

Picamilon Breakdown in the Brain

SCIENTIFIC DATA VISUALIZATION

Y-Axis
Effect Action
Component →

Health Benefits & Sources

Why You Need It

  • Promotes Relaxation: May help reduce feelings of stress and anxiety by interacting with brain receptors.
  • Supports Healthy Blood Flow: The niacin component helps dilate blood vessels, potentially improving circulation to the brain.
  • Mood Enhancement: Some users report a subtle 'calm focus' effect without the drowsiness of sedatives.

Deep Dive

Picamilon works by bypassing the body's usual transport systems for GABA. While GABA taken orally usually doesn't cross the blood-brain barrier, Picamilon's chemical structure allows it to slip through. Once in the brain, enzymes break it down, releasing GABA and Niacin. The GABA may help quiet overactive nerve activity, while the Niacin supports metabolic energy in brain cells. It is distinct from prescription drugs like Xanax or Valium; it is generally considered a milder, non-habit-forming option for managing mild stress.

Natural Food Sources

Crucial Note: Picamilon is a synthetic compound. It does not exist naturally in fruits, vegetables, or any whole foods. You cannot eat your way to Picamilon.

However, you can consume the precursors separately:

PrecursorNatural SourcesBenefit
Niacin (B3)Chicken, Tuna, Peanuts, AvocadoEnergy & Brain Health
GABATea, Tomatoes, Spinach, Fermented FoodsCalming Support

Supplementation

Picamilon is available only as a dietary supplement (powder or capsule).

  • Typical Dosage: 150mg – 500mg daily.
  • Timing: Usually taken in the morning for focus or in the evening for relaxation.
  • Who should take it: Adults looking for non-prescription support for mild anxiety or mental fatigue. Always consult a doctor first.

Top Food Sources

Picamilon
Synthetic only
Chicken Breast
Natural B3 source
Spinach
Natural calming amino source
Brown Rice
Fermented/Whole grain
Avocado
Brain health fats

Frequently Asked Questions

No. Standard GABA supplements struggle to cross the blood-brain barrier. Picamilon is engineered to cross it, where it then breaks down into GABA and Niacin.
Yes, sometimes. The Niacin component can cause temporary skin redness, itching, or warmth, especially at higher doses.
Yes, it is legal to buy as a dietary supplement, though the FDA has warned manufacturers against marketing it as a drug.
Effects are usually felt within 30 to 60 minutes and can last for several hours.

Safety & Side Effects

Safety & Side Effects

Picamilon is generally well-tolerated, but because it affects brain chemistry and blood vessels, caution is required.

Common Side Effects:

  • Headache (often caused by the niacin flush)
  • Dizziness or lightheadedness
  • Nausea or stomach upset

Who Should Avoid It:

  • Pregnant or breastfeeding women: Safety has not been established.
  • People with liver conditions: High doses of Niacin can stress the liver.
  • People with low blood pressure: Since it dilates blood vessels, it may lower BP further.

Important Warning: The FDA has cracked down on companies selling Picamilon as a 'new drug' rather than a supplement. Ensure you buy from reputable sources that strictly label it as a dietary ingredient.

Scientific References

  • [1]N Institute of Health: Dietary Supplement Label Database
  • [2]Journal of Medicinal Food: Bioavailability of GABA derivatives
  • [3]FDA Warning Letters regarding Picamilon enforcement