PLGA
Bio-Activity Analysis
Dietary Intake vs. Body Production
SCIENTIFIC DATA VISUALIZATION
Health Benefits & Sources
Why You Need It (Natural Sources)
- Hydration Regulation: PLGA acts as an osmolyte, helping your cells manage water balance efficiently. This is crucial for keeping your tissues hydrated and your kidneys functioning smoothly.
- Cognitive Support: It acts as a precursor to glutamate, a major neurotransmitter. This helps with learning and memory formation.
- Antioxidant Booster: By participating in the glutathione cycle, it helps your body recycle its most powerful internal antioxidant, protecting cells from damage.
How It Works
Your body produces PLGA naturally as part of the glutathione cycle. However, you can also get it directly from your diet. Once consumed, it helps buffer acidity in the body and supports the synthesis of important brain chemicals. Unlike harsh synthetic additives, natural PLGA from food is utilized gently by the body.
Natural Food Sources
PLGA is found in high concentrations in fermented foods and certain fruits. Eating a varied diet usually provides sufficient amounts.
| Food | Amount | % DV |
|---|---|---|
| Beets (Cooked) | High | ~40% |
| Fermented Foods | Medium-High | ~30% |
| Wheat Germ | Medium | ~20% |
| Apples | Low-Medium | ~10% |
| Broccoli | Low | ~5% |
Supplementation
Dosage: Most studies suggest that 500mg to 1000mg daily is safe for general support, though food sources are preferred.
Who Should Take It: It is generally considered safe for healthy adults looking to support hydration and cognitive function. However, because it influences acidity levels, those with metabolic issues should consult a doctor first.
Top Food Sources
Frequently Asked Questions
Safety & Side Effects
Safety Profile
General Safety: PLGA is Generally Recognized As Safe (GRAS) by the FDA when used in normal food amounts.
Side Effects: High doses (above 2g) may cause mild gastrointestinal upset, such as nausea or stomach cramping.
Interactions: It can alter urine acidity. Be cautious if you are taking medications that are sensitive to pH levels (like certain anticonvulsants or salicylates).
Who Should Avoid: Individuals with severe kidney disease or metabolic acidosis should avoid PLGA supplements unless directed by a physician.
Scientific References
- [1]Rogers, Q. R., & Morris, J. G. (1979). 'Pyroglutamic acid: A normal constituent of the diet.' *The Journal of Nutrition*.
- [2]Hawkins, R. A., et al. (2006). 'The role of pyroglutamate in brain energy metabolism.' *Neurochemical Research*.
- [3]US Food and Drug Administration (FDA). 'GRAS Notices for Pyroglutamic Acid.'