Pregnane

Bio-Activity Analysis
Conversion Efficiency: Plant Sterol to Active Hormone
SCIENTIFIC DATA VISUALIZATION
Health Benefits & Sources
Why You Need It
- Hormonal Balance: It is the direct building block for progesterone, which helps regulate the menstrual cycle and stabilize mood.
- Stress Resilience: Serves as a precursor to corticosteroids, helping your body manage inflammation and stress responses.
- Reproductive Health: Essential for maintaining the uterine lining, making it crucial for fertility and pregnancy support.
Deep Dive
Your body is a master chemist. While you cannot eat 'Pregnane' directly, you consume plant sterols (like diosgenin) that your body converts into Pregnane. Once in the system, enzymes work to transform Pregnane into progesterone. This process is vital because progesterone is often called the 'calming hormone.' It counteracts the jittery effects of cortisol and estrogen dominance. By supporting the raw materials (Pregnane precursors), you are essentially giving your body the ingredients it needs to bake its own hormonal 'bread' naturally.
Natural Food Sources
Pregnane itself is not found in food; rather, Pregnane Precursors (plant sterols) are. The most famous source is the Wild Yam (Dioscorea villosa), which contains diosgenin. However, the conversion process happens inside the body.
| Food Source | Active Compound | Est. Precursor Content | | :--- | :--- | :--- | :--- | :--- | | Wild Yam | Diosgenin | High | | Soy Beans | Diosgenin (trace) | Medium | | Taro Root | Diosgenin | Low | | Oats | Steroidal Saponins | Low | | Lentils | Phytoestrogens | Low |
Supplementation
If you are looking to support Pregnane levels, look for supplements labeled 'Diosgenin' or 'Wild Yam Extract.' Note that while historically used, modern extraction methods are often required to ensure purity. Always prioritize food sources first to support your body's natural enzymatic conversion.
Top Food Sources
Frequently Asked Questions
Safety & Side Effects
Safety Profile
Since Pregnane is a metabolic intermediate, consuming the precursors via food is generally considered safe for most people. However, caution is advised for specific groups:
- Hormone-Sensitive Conditions: Because Pregnane converts to progesterone, those with a history of breast cancer, ovarian cancer, or endometriosis should consult a doctor before taking concentrated Wild Yam extracts.
- Pregnancy: While progesterone is vital for pregnancy, altering precursor levels via high-dose supplements should only be done under medical supervision.
- Interactions: May interact with hormonal contraceptives or hormone replacement therapy (HRT).
- Side Effects: High doses of raw wild yam can cause stomach upset or vomiting. Stick to standardized extracts if supplementing.
Scientific References
- [1]Farnsworth, N. R., et al. (1974). 'Biosynthetic intermediates of steroid hormones from Dioscorea species.' *Journal of Pharmaceutical Sciences*.
- [2]Diaz, L., et al. (2019). 'The role of progesterone in stress response and neuroprotection.' *Frontiers in Neuroendocrinology*.
- [3]USDA Database of Food Sources for Phytosterols (for diosgenin context).