Premna

Bio-Activity Analysis
Mechanism of Action: Inflammatory Pathway Inhibition
SCIENTIFIC DATA VISUALIZATION
Health Benefits & Sources
Why You Need It
- Stress & Mood Resilience: Premna is an adaptogen, meaning it helps normalize cortisol levels, reducing the physical impact of stress.
- Natural Pain Relief: It contains specific compounds (like acteoside) that inhibit inflammatory pathways, making it excellent for joint comfort.
- Metabolic Boost: It supports healthy digestion and metabolism, historically used to treat digestive sluggishness.
Deep Dive
Premna works primarily through its rich profile of phenylethanoids and flavonoids. These compounds act as potent antioxidants, scavenging free radicals that damage healthy cells. For the everyday person, this translates to less oxidative wear and tear after a long day or a hard workout. Studies suggest it modulates the immune system, preventing it from overreacting (which leads to inflammation) or underreacting (which leads to illness). It is particularly noted for its 'vata-pacifying' properties in Ayurveda, helping to ground the body and improve sleep quality.
Natural Food Sources
Premna is a botanical extract. You won't find it in the produce aisle of a standard grocery store. It is consumed traditionally in parts of India and Southeast Asia as a medicinal tea or decoction of the leaves and roots.
Supplementation
Since natural dietary sources are rare outside of its native regions, supplementation is the standard route.
- Dosage: Standardized extracts typically range from 300mg to 600mg daily.
- Format: Usually found in capsule form or as a component of 'Chyawanprash' (an Ayurvedic jam).
- Who Should Take It: Individuals dealing with chronic low-grade inflammation, high stress, or metabolic sluggishness.
Top Food Sources
Frequently Asked Questions
Safety & Side Effects
Safety & Side Effects
Premna is generally considered very safe with a low toxicity profile.
- Side Effects: Rare, but mild gastrointestinal upset can occur if taken on an empty stomach.
- Interactions: There are no widely reported severe drug interactions, but because it can lower blood sugar and blood pressure, use caution if you are on medication for diabetes or hypertension.
- Pregnancy: Due to a lack of clinical safety data, pregnant or breastfeeding women should avoid supplementation and stick to food-based nutrients.
Scientific References
- [1]Pharmacological Review of Premna serratifolia L. (Agnimantha) - Journal of Ethnopharmacology
- [2]Anti-inflammatory and analgesic activity of Premna serratifolia - Indian Journal of Pharmacology
- [3]Adaptogenic activity of Premna corymbosa - Ancient Science of Life