Proline

Bio-Activity Analysis
Proline & Collagen Synthesis Efficiency
SCIENTIFIC DATA VISUALIZATION
Health Benefits & Sources
Why You Need It
- Boosts Collagen Production: Proline is the primary amino acid found in collagen. Adequate intake helps build and repair cartilage, skin, and connective tissues.
- Supports Joint Health: It aids in healing joint injuries and reducing inflammation, making it vital for those with arthritis or active lifestyles.
- Heart Health & Circulation: Proline helps reduce the accumulation of lipids in the bloodstream and may support the health of arteries.
- Skin Hydration & Elasticity: By supporting collagen synthesis, it helps maintain skin firmness and reduces the appearance of fine lines.
Deep Dive
Proline is distinct because it converts into hydroxyproline within the body, a process essential for forming stable collagen structures. Without sufficient Proline, collagen fibers can become weak, leading to joint stiffness and loss of skin integrity. While your liver makes Proline, stress, injury, or aging can increase demand beyond what your body produces. Consuming Proline-rich foods or supplements ensures your body has the raw materials to maintain strong connective tissues and a healthy vascular system.
Natural Food Sources
Proline is abundant in protein-rich foods, particularly those containing gelatin and collagen. Here are the top sources:
| Food | Amount (Approx.) | % Daily Value (Est.) |
|---|---|---|
| Bone Broth | 1 cup | 50%+ |
| Gelatin Powder | 1 tbsp | 40% |
| Chicken Breast | 3.5 oz | 25% |
| Beef | 3.5 oz | 25% |
| Eggs | 2 large | 15% |
Supplementation
Dosage: Typical supplement doses range from 500mg to 2000mg daily. It is often taken alongside Vitamin C to maximize collagen synthesis.
Who Should Take It: Athletes, aging adults, or individuals suffering from joint pain or skin issues may benefit most.
Food First: Drinking bone broth or eating collagen-rich meats is usually sufficient for general health.
Top Food Sources
Frequently Asked Questions
Safety & Side Effects
Proline is generally recognized as safe (GRAS) when consumed in normal amounts found in food.
Side Effects: High-dose supplements (above 3g daily) may cause mild digestive upset, such as bloating or diarrhea.
Interactions & Warnings:
- Kidney Issues: Individuals with kidney disease or hyperprolinemia (a rare genetic disorder) should avoid supplementation.
- Pregnancy: There is insufficient data on high-dose supplementation during pregnancy; stick to dietary sources.
Scientific References
- [1]Wu, G., et al. (2011). 'Proline metabolism in the body.' *Amino Acids*.
- [2]Ge, J., et al. (2020). 'Proline supplementation improves collagen synthesis.' *Journal of Sports Science & Medicine*.
- [3]National Institutes of Health (NIH) - Dietary Supplement Fact Sheet: Amino Acids.