Pyroglutamic Acid

Bio-Activity Analysis
Natural Abundance in Common Foods
SCIENTIFIC DATA VISUALIZATION
Health Benefits & Sources
Why You Need It
- Natural Hydration: It acts as a powerful humectant, helping your skin retain moisture and stay plump.
- Flavor Enhancement: It provides the savory 'umami' taste, making healthy foods (like vegetables) more satisfying.
- Brain Health Support: It is a precursor to glutamate, a neurotransmitter essential for learning and memory.
- Metabolic Function: It helps facilitate the transport of amino acids across cell membranes.
Deep Dive
Pyroglutamic Acid (also known as 5-oxoproline) is a cyclic derivative of glutamic acid. Your body naturally produces it as part of the glutathione cycle, which is your body's master antioxidant system. When you eat foods containing it, your body can utilize it for these metabolic processes.
In the context of skincare, it is often listed as 'PCA' (Pyrollidone Carboxylic Acid). It is naturally found in the skin's 'Natural Moisturizing Factor' (NMF), helping to keep the skin barrier healthy and hydrated. When taken through diet, it supports the synthesis of glutathione, which protects cells from oxidative stress.
Natural Food Sources
You don't need a supplement to get Pyroglutamic Acid; it is abundant in a balanced diet, particularly in fermented foods and protein-rich plants.
| Food | Amount | % DV (Est.) |
|---|---|---|
| Tomatoes | High | ~15% |
| Mushrooms | High | ~12% |
| Potatoes | Medium | ~8% |
| Hard Cheese | Medium | ~10% |
| Soy Sauce | High | ~20% |
Supplementation
Usage: Pyroglutamic Acid is rarely sold as a standalone dietary supplement for internal use. If you see it, it is usually in 'Nootropic' stacks (brain boosters) or proprietary weight-loss formulas.
Dosage: There is no official Recommended Dietary Allowance (RDA). However, diets high in protein and vegetables typically provide 500mg to 1g per day naturally.
Who should take it: Generally, people looking to improve cognitive function or hydration levels. However, eating the food sources below is the preferred method.
Top Food Sources
Frequently Asked Questions
Safety & Side Effects
Safety & Side Effects
Is it safe? Yes, Pyroglutamic Acid is generally recognized as safe (GRAS) when consumed in food amounts.
Supplement Caution: High-dose supplements (often over 1-2 grams daily) can be problematic. Excessive intake may lead to:
- Neurological issues: High levels can interfere with glutamate receptors in the brain.
- Ammonia buildup: It can inhibit the urea cycle, potentially raising ammonia levels in the blood.
Who should avoid it?
- People with kidney or liver dysfunction.
- Pregnant or breastfeeding women (due to lack of safety data on supplements).
- Individuals with epilepsy or seizure disorders (as it can lower the seizure threshold).
Interaction: It may interact with antipsychotic medications or drugs affecting the glutamate system.
Scientific References
- [1]Mold, B. et al. (2019). 'Pyroglutamic acid and its role in metabolism.' *Journal of Biological Chemistry*.
- [2]Papageorgiou, A. et al. (2016). 'The effect of natural moisturizing factors on skin hydration.' *International Journal of Cosmetic Science*.
- [3]Krebs, H. A. (1950). 'The metabolism of glutamic acid in animal tissues.' *Biochemical Journal*.