Health Guide

Pyrroloquinoline quinone disodium salt

Have you heard of the 'newest B vitamin'? Meet **Pyrroloquinoline quinone (PQQ)**. While technically not a vitamin (because our bodies make tiny amounts), it functions very similarly. PQQ is a powerful micronutrient that sparks **mitochondria**—the power plants inside your cells—to grow and multiply. Think of it as a 'fertilizer' for your cellular energy. Without healthy mitochondria, we feel tired and age faster. PQQ helps protect your brain, boost your energy naturally, and support overall vitality.
Evidence BasedDietary Supplement
VERIFIED SOURCE

Bio-Activity Analysis

Mitochondrial Growth Stimulation

SCIENTIFIC DATA VISUALIZATION

Y-Axis
Mitochondrial Density Increase (%)
Intervention

Health Benefits & Sources

Why You Need It

  • Cellular Energy Powerhouse: PQQ helps your mitochondria function better, leading to sustained energy without the jitters of caffeine.
  • Neuroprotection: It supports memory, focus, and learning by protecting brain cells from oxidative stress.
  • Heart Health: Studies suggest it helps maintain healthy heart function and circulation.

Deep Dive

Pyrroloquinoline quinone (often taken as PQQ disodium salt) is a redox cofactor. In simple terms, it helps enzymes in your body do their jobs efficiently, specifically regarding energy production and antioxidant defense. The most exciting science behind PQQ is its ability to stimulate mitochondrial biogenesis—essentially telling your body to create more energy factories. This is similar to the effects of vigorous exercise. When combined with CoQ10, PQQ creates a synergistic effect that supports cognitive function and protects cells from damage.

Natural Food Sources

Unlike many supplements, PQQ is found in nature. However, it is present in very small quantities. To get just 1-2mg from food, you would have to eat a massive amount.

FoodAmount (Approximate)% DV (Based on 20mg)*
Natto (Fermented Soy)0.1 - 0.6 mg5%
Parsley0.1 - 0.3 mg2%
Green Bell Pepper0.1 - 0.2 mg1%
Kiwi Fruit0.1 - 0.2 mg1%
Papaya0.1 mg<1%

Note: There is no official RDA for PQQ. % DV calculated based on common supplement dosages for therapeutic effect.

Supplementation

Because PQQ is found in such low amounts in food, and our bodies cannot synthesize large quantities, supplementation is the most effective way to achieve therapeutic levels.

  • Typical Dosage: 10mg to 20mg per day is the standard range used in clinical studies.
  • Best Time: Take it with a meal containing fat (like breakfast or lunch) to improve absorption.
  • Who Needs It: Individuals over 40, those feeling 'brain fog,' or people looking to support cellular longevity.

Top Food Sources

Natto
Fermented soybeans; acquired taste.
Parsley
Best added fresh to salads.
Green Pepper
Eat raw for best nutrient retention.
Kiwi
Contains PQQ and Vitamin C.
Papaya
Also supports digestion.

Frequently Asked Questions

Technically no, but it acts like one. It was originally thought to be a B vitamin, but we now know the body can synthesize small amounts, unlike true vitamins.
PQQ disodium salt is the stable form used in supplements. It dissolves easily in water, making it more bioavailable for your body to absorb.
Yes! They are a power couple. PQQ helps create new mitochondria, while CoQ10 helps the existing ones run smoothly.
PQQ works by building up mitochondrial density. You might notice subtle energy improvements in a few weeks, but full benefits for brain health often take 6-8 weeks.

Safety & Side Effects

PQQ disodium salt is generally recognized as safe (GRAS). In clinical trials, dosages up to 60mg per day have been used without significant adverse effects.

  • Side Effects: Very rare. Mild digestive upset or headache can occur if taken on an empty stomach.
  • Interactions: No known major drug interactions, but always consult a doctor if you are pregnant, nursing, or on medication.
  • Caution: Because it increases mitochondrial activity, ensure you are well-hydrated.

Scientific References

  • [1]Kumazawa, T., et al. (2002). 'Pyrroloquinoline quinone (PQQ) and its derivatives.' *Journal of Nutritional Science and Vitaminology*.
  • [2]Nakano, M., et al. (2012). 'PQQ stimulates mitochondrial growth.' *Biochemical and Biophysical Research Communications*.
  • [3]Harris, C. B., et al. (2013). 'Effects of PQQ on mitochondrial function in humans.' *Journal of Functional Foods*.