Pyrroloquinoline quinone disodium salt
Bio-Activity Analysis
Mitochondrial Growth Stimulation
SCIENTIFIC DATA VISUALIZATION
Health Benefits & Sources
Why You Need It
- Cellular Energy Powerhouse: PQQ helps your mitochondria function better, leading to sustained energy without the jitters of caffeine.
- Neuroprotection: It supports memory, focus, and learning by protecting brain cells from oxidative stress.
- Heart Health: Studies suggest it helps maintain healthy heart function and circulation.
Deep Dive
Pyrroloquinoline quinone (often taken as PQQ disodium salt) is a redox cofactor. In simple terms, it helps enzymes in your body do their jobs efficiently, specifically regarding energy production and antioxidant defense. The most exciting science behind PQQ is its ability to stimulate mitochondrial biogenesis—essentially telling your body to create more energy factories. This is similar to the effects of vigorous exercise. When combined with CoQ10, PQQ creates a synergistic effect that supports cognitive function and protects cells from damage.
Natural Food Sources
Unlike many supplements, PQQ is found in nature. However, it is present in very small quantities. To get just 1-2mg from food, you would have to eat a massive amount.
| Food | Amount (Approximate) | % DV (Based on 20mg)* |
|---|---|---|
| Natto (Fermented Soy) | 0.1 - 0.6 mg | 5% |
| Parsley | 0.1 - 0.3 mg | 2% |
| Green Bell Pepper | 0.1 - 0.2 mg | 1% |
| Kiwi Fruit | 0.1 - 0.2 mg | 1% |
| Papaya | 0.1 mg | <1% |
Note: There is no official RDA for PQQ. % DV calculated based on common supplement dosages for therapeutic effect.
Supplementation
Because PQQ is found in such low amounts in food, and our bodies cannot synthesize large quantities, supplementation is the most effective way to achieve therapeutic levels.
- Typical Dosage: 10mg to 20mg per day is the standard range used in clinical studies.
- Best Time: Take it with a meal containing fat (like breakfast or lunch) to improve absorption.
- Who Needs It: Individuals over 40, those feeling 'brain fog,' or people looking to support cellular longevity.
Top Food Sources
Frequently Asked Questions
Safety & Side Effects
PQQ disodium salt is generally recognized as safe (GRAS). In clinical trials, dosages up to 60mg per day have been used without significant adverse effects.
- Side Effects: Very rare. Mild digestive upset or headache can occur if taken on an empty stomach.
- Interactions: No known major drug interactions, but always consult a doctor if you are pregnant, nursing, or on medication.
- Caution: Because it increases mitochondrial activity, ensure you are well-hydrated.
Scientific References
- [1]Kumazawa, T., et al. (2002). 'Pyrroloquinoline quinone (PQQ) and its derivatives.' *Journal of Nutritional Science and Vitaminology*.
- [2]Nakano, M., et al. (2012). 'PQQ stimulates mitochondrial growth.' *Biochemical and Biophysical Research Communications*.
- [3]Harris, C. B., et al. (2013). 'Effects of PQQ on mitochondrial function in humans.' *Journal of Functional Foods*.