Sulphoraphane

Bio-Activity Analysis
Sulforaphane Potential: Raw vs. Cooked
SCIENTIFIC DATA VISUALIZATION
Health Benefits & Sources
Why You Need It
- Cellular Detoxification: Activates the Nrf2 pathway, which triggers your body's production of antioxidant enzymes.
- Brain Protection: Increases levels of Brain-Derived Neurotrophic Factor (BDNF), supporting memory and cognitive function.
- Anti-Inflammatory: Lowers markers of inflammation (like NF-kB) throughout the body.
Deep Dive
Sulforaphane is a sulfur-rich compound found in cruciferous vegetables. It is technically a 'phytonutrient' that works on a genetic level. Unlike standard antioxidants that simply scavenge free radicals, Sulforaphane turns on the genes that manufacture your own internal antioxidant army (such as Glutathione).
Research suggests it helps the liver process toxins more efficiently and may protect the brain against oxidative stress. It is particularly popular for its potential to support focus and mental clarity, earning it the nickname 'broccoli brain booster'.
Natural Food Sources
Sulforaphane is not found directly in the plant; it is formed when a precursor called glucoraphanin mixes with the enzyme myrosinase. This happens when the plant is chopped, chewed, or damaged. Crucially, cooking can destroy the enzyme, preventing Sulforaphane formation.
| Food | Amount | % DV (Estimate) |
|---|---|---|
| Broccoli Sprouts | 1 oz (30g) | 500%+ |
| Broccoli Florets | 1 cup | 70% |
| Kale | 1 cup | 50% |
| Brussels Sprouts | 1 cup | 45% |
| Cauliflower | 1 cup | 30% |
Supplementation
Because raw sprouts are the most potent source, eating enough daily can be difficult.
- When to supplement: If you dislike the taste of broccoli or want therapeutic doses for cognitive or inflammatory support.
- Tip: Look for supplements that contain both glucoraphanin and myrosinase (often labeled as "active" or "stabilized" sulforaphane).
Top Food Sources
Frequently Asked Questions
Safety & Side Effects
Sulforaphane is generally considered safe and is well-tolerated at dietary levels.
Potential Side Effects: High-dose supplements may cause mild stomach upset or gas in some individuals.
Medication Interactions: Because Sulforaphane affects liver enzymes (specifically CYP450), it may interact with blood thinners (like Warfarin) or certain chemotherapy drugs. Consult a doctor before starting concentrated supplements if you are on prescription medication.
Who Should Avoid: People with hypothyroidism should consume cruciferous vegetables in moderation, as goitrogens (present in raw forms) can interfere with thyroid function, though cooked versions are safer.
Scientific References
- [1]University of California, Davis. (2013). *Study on Sulforaphane's bioavailability and speed of action.*
- [2]Journal of Neuroscience. (2013). *Sulforaphane improves memory in older adults.*
- [3]NIH Office of Dietary Supplements. *Fact Sheet for Health Professionals: Broccoli and Sulforaphane.*