Threonine alpha-hydroxyisocaproic acid

Bio-Activity Analysis
Protein Synthesis Stimulation (Relative Activity)
SCIENTIFIC DATA VISUALIZATION
Health Benefits & Sources
Why You Need It
- Muscle Health & Recovery: Threonine helps prevent muscle breakdown during exercise and supports the repair of tissue.
- Gut & Digestion: It is a key component of mucin, a protein that creates a protective lining in your stomach and intestines, helping to prevent issues like 'leaky gut.'
- Nervous System Support: It aids in the production of glycine and serine, amino acids essential for a healthy nervous system.
- Collagen Production: It supports the synthesis of collagen and elastin, keeping skin and connective tissue healthy.
Deep Dive
Threonine is one of the three amino acids that form the structural backbone of collagen (along with glycine and proline). Without adequate Threonine, your body struggles to build the collagen needed for skin elasticity and joint health. Additionally, because it converts to glycine in the brain, it plays a subtle but important role in maintaining a calm, balanced mood and supporting cognitive function.
Natural Food Sources
You can easily meet your needs through a balanced diet. Animal proteins are the most concentrated sources, but plant-based options are effective too.
| Food | Amount | % DV (approx) |
|---|---|---|
| Canned Sardines | 3 oz | 78% |
| Chicken Breast | 3 oz | 58% |
| Pumpkin Seeds | 1 oz | 45% |
| Greek Yogurt | 1 cup | 40% |
| Lentils | 1 cup cooked | 35% |
Supplementation
If you follow a strict vegan diet or have high-intensity training demands, you might consider a supplement. For the 'Alpha-Hydroxyisocaproic Acid' (HICA) form, typical dosages in studies range from 1.5 to 3 grams per day, often taken post-workout to aid in reducing muscle soreness (DOMS).
Top Food Sources
Frequently Asked Questions
Safety & Side Effects
Threonine is generally recognized as safe (GRAS) when taken within recommended dietary allowances. High doses (above 5g daily) can cause mild side effects like nausea or stomach upset. Those with Liver Disease or Amyotrophic Lateral Sclerosis (ALS) should consult a doctor before supplementing, as amino acid metabolism can be altered in these conditions.
Scientific References
- [1]Le, B., & Yang, S. H. (2018). 'Threonine in collagen structure and function.' *Amino Acids*.
- [2]Tipton, K. D., & Wolfe, R. R. (2001). 'Exercise, protein metabolism, and muscle growth.' *International Journal of Sport Nutrition and Exercise Metabolism*.
- [3]Holecek, M. (2017). 'Branched-chain amino acids and threonine in health and disease.' *Journal of Nutrition & Intermediary Metabolism*.