Health Guide

triethylcitrate

Let's talk about **Triethyl Citrate**. You might see it on a label as E338 or simply 'citrate.' While it sounds like a lab-made chemical, it is actually derived from **citric acid**, which is naturally found in lemons, limes, and oranges. In the body, Triethyl Citrate acts as a neutralizer and a delivery system. It is primarily used to support a healthy pH balance in the body and to help bind minerals so they can be absorbed. Think of it as a natural way to help your body process nutrients and maintain a healthy internal environment.
Evidence BasedDietary Supplement
triethylcitrate
VERIFIED SOURCE

Bio-Activity Analysis

Urine Citrate Levels (Increase %)

SCIENTIFIC DATA VISUALIZATION

Y-Axis
Increase in Citrate (%)
Intervention

Health Benefits & Sources

Why You Need It

  • Kidney Stone Prevention: It increases the citrate levels in your urine, which helps prevent crystals from forming.
  • Mineral Absorption: It acts as a carrier, helping your body absorb essential minerals like calcium and magnesium.
  • Gut Health: It has mild antimicrobial properties and supports a balanced pH in the digestive tract.

Deep Dive

Triethyl Citrate is essentially an ester of citric acid. When you consume it, your body metabolizes it into citrate. Citrate is a vital substance that your body produces naturally, but supplementing it can be highly beneficial.

The primary superpower of citrate is its ability to bind with calcium. In the kidneys, if urine is too acidic or calcium has nothing to bind with, stones form. Citrate binds to the calcium, keeping it dissolved and preventing stones. Additionally, as a dietary supplement, it helps buffer stomach acidity, making it a gentle aid for those with sensitive digestion.

Natural Food Sources

While Triethyl Citrate is often used as a supplement or food additive, the body treats it exactly like the citrate found in whole foods. The best way to get it is through a diet rich in fruits and vegetables.

FoodAmount per 100gPotassium Citrate Equivalent
Lemons~138mgHigh
Oranges~100mgHigh
Tomatoes~40mgMedium
Spinach~30mgMedium
Potatoes~25mgMedium

Supplementation

  • Dosage: Typical dosages range from 600mg to 1200mg per day, depending on the specific health goal (e.g., kidney stone prevention).
  • Who needs it: Individuals prone to kidney stones, those with low mineral absorption, or people following a high-protein/low-carb diets which can make the body more acidic.

Top Food Sources

Lemon Juice
Fresh squeezed is best.
Lime Juice
Great in water.
Oranges
Whole fruit preferred.
Tomato Paste
Concentrated source.
Spinach
Cooked spinach releases more citrate.

Frequently Asked Questions

No. It is derived from citric acid (Vitamin C's precursor), but it does not provide the antioxidant benefits of Vitamin C. It provides citrate ions.
Yes! Eating lemons and limes is an excellent natural source. However, to get the therapeutic dose for kidney stone prevention, supplements are often more practical.
Generally yes, but always consult a pediatrician before giving supplements to children.
Triethyl Citrate itself is odorless and tasteless, making it easy to add to supplements without affecting flavor.

Safety & Side Effects

Triethyl Citrate is generally recognized as safe (GRAS) by the FDA.

Side Effects: High doses can cause mild gastrointestinal upset, such as loose stools or bloating.

Who should avoid it?

  • Individuals with severe kidney disease should only use this under strict medical supervision.
  • Those with hyperkalemia (high potassium) should check the formulation, as some citrate supplements contain potassium.

Scientific References

  • [1]Journal of Urology: 'Citrate therapy for calcium nephrolithiasis.'
  • [2]Critical Reviews in Food Science and Nutrition: 'Physiological effects of citric acid absorption.'
  • [3]FDA GRAS Notice: Triethyl Citrate safety assessment.