DrFeb
Health Guide

Valine alpha-ketoglutarate

Valine alpha-ketoglutarate (VAKG) is a specialized dietary supplement formed by bonding the Branched-Chain Amino Acid (BCAA) 'Valine' with 'Alpha-Ketoglutarate' (a key molecule in cellular energy production). Often used by athletes and those focusing on muscle recovery, this compound is designed to bypass standard digestion to deliver raw building blocks directly to your tissues. Think of it as a high-efficiency fuel source for your muscles, helping to reduce fatigue, speed up recovery after workouts, and support lean muscle mass maintenance as you age.
Evidence BasedDietary Supplement
Valine alpha-ketoglutarate
VERIFIED SOURCE

Bio-Activity Analysis

Muscle Protein Synthesis Stimulation

SCIENTIFIC DATA VISUALIZATION

Y-Axis
Effectiveness (Relative)
Source Type →

Health Benefits & Sources

Why You Need It

  • Accelerated Muscle Recovery: Helps repair micro-tears in muscle fibers after exercise.
  • Reduced Exercise Fatigue: Acts as a fuel source for muscles, delaying exhaustion.
  • Metabolic Support: Alpha-Ketoglutarate plays a vital role in the Krebs cycle, your body's energy engine.
  • Nitric Oxide Production: May support blood flow and nutrient delivery to active tissues.

Deep Dive

Valine is one of three essential Branched-Chain Amino Acids (along with Leucine and Isoleucine). Unlike other amino acids, BCAAs are metabolized directly in the muscle rather than the liver. By combining Valine with Alpha-Ketoglutarate (AKG), the body gets a dual-action supplement: the amino acid repairs tissue, while the AKG supports cellular energy and waste removal (via ammonia buffering). This makes it particularly popular in bodybuilding circles and for elderly individuals looking to combat age-related muscle loss (sarcopenia).

Natural Food Sources

It is important to note that Valine alpha-ketoglutarate (VAKG) is a specific chemical complex found almost exclusively in high-quality protein supplements. You cannot eat a specific fruit or vegetable to get this exact compound. However, you can consume the two separate components naturally:

FoodComponentAmount
Chicken BreastValine (BCAA)High
SalmonValine (BCAA)High
Pumpkin SeedsValine (BCAA)Medium
SpinachAlpha-Ketoglutarate (precursor)Low
Red MeatAlpha-Ketoglutarate (precursor)Medium

Supplementation

VAKG is typically found in powdered form or inside capsule blends.

  • Dosage: Standard dosages range from 500mg to 2000mg daily, often taken pre- or post-workout.
  • Who Should Take It: Endurance athletes, bodybuilders, and older adults concerned with muscle wasting.
  • Food First: Prioritize high-protein foods (meat, dairy, legumes) to get natural BCAAs. Supplements are useful for hitting specific performance targets.

Top Food Sources

Chicken Breast
Natural source of Valine
Whey Protein
Often contains VAKG in blends
Beef
Rich in BCAAs
Tofu
Plant-based Valine source
Almonds
Snack source for amino acids

Frequently Asked Questions

No. The addition of alpha-ketoglutarate (AKG) is intended to improve the absorption and utilization of the Valine. AKG also plays its own role in energy production and ammonia buffering.
No. You cannot get the specific VAKG compound from vegetables. However, vegetables like spinach contain small amounts of AKG precursors, and legumes contain Valine.
Indirectly. By preserving lean muscle mass during a calorie deficit, it helps maintain a higher metabolic rate, which can assist in weight management.
Yes. BCAAs and AKG are permitted supplements for most sports organizations, including the IOC and NCAA.

Safety & Side Effects

Safety & Side Effects

General Safety: For most healthy adults, VAKG is generally well-tolerated when used in moderation.

Potential Side Effects:

  • Nausea/Stomach Upset: High doses of amino acids can sometimes cause gastrointestinal distress.
  • Blood Sugar: Alpha-Ketoglutarate can theoretically interact with blood sugar levels; use caution if you are diabetic.

Who Should Avoid It:

  • Pregnant/Breastfeeding Women: Due to a lack of safety data in these populations, avoid supplementation.
  • Kidney Disease: If your kidneys are compromised, processing high amounts of amino acids and nitrogen byproducts can be dangerous.
  • Medications: If you take blood thinners or immunosuppressants, consult a doctor first.

Scientific References

  • [1]Brosnan, J. T., & Brosnan, M. E. (2006). Branched-chain amino acids: enzyme and substrate regulation. *Journal of Nutrition*.
  • [2]Williams, M. H. (2005). Dietary supplements and sports performance: amino acids. *Journal of the International Society of Sports Nutrition*.
  • [3]Cynober, L. (2006). Alpha-ketoglutarate: physiological and clinical applications. *Current Opinion in Clinical Nutrition & Metabolic Care*.