Health Guide

Yohimbine

Yohimbine is an active compound derived from the bark of the *Pausinystalia yohimbe* tree, native to Central and Western Africa. Traditionally used as an aphrodisiac, it has gained modern popularity primarily as a fat-burning and performance-enhancing supplement. Chemically, it functions as an alpha-2 adrenergic antagonist. In plain English, this means it blocks specific receptors in the body that usually suppress fat burning and blood flow, effectively 'turning off' the brake pedal and allowing your body to mobilize stored fat for energy. While it is a potent compound, it requires careful dosing and is not found in standard fruits or vegetables.
Evidence BasedDietary Supplement
Yohimbine
VERIFIED SOURCE

Bio-Activity Analysis

Effectiveness by Insulin State

SCIENTIFIC DATA VISUALIZATION

Y-Axis
Lipolytic Activity (Fat Breakdown)
Physiological State

Health Benefits & Sources

Why You Need It

  • Targeted Fat Loss: It helps mobilize stubborn fat stores, particularly in the lower abdomen and thighs.
  • Enhanced Physical Performance: It can improve oxygen uptake and blood flow (vasodilation) during exercise.
  • Libido Support: Historically used to support sexual health and drive.

Deep Dive

Yohimbine works by antagonizing alpha-2 adrenergic receptors. These receptors are often found in areas of the body where blood flow is restricted or fat is hard to burn (like the belly). When these receptors are blocked, the body releases norepinephrine, a neurotransmitter that triggers lipolysis (fat breakdown). It effectively fights against the body's natural tendency to store fat in these regions. However, it is a stimulant, meaning it increases heart rate and blood pressure. It is most effective when used in conjunction with exercise and a caloric deficit.

Natural Food Sources

Unlike vitamins or minerals, Yohimbine is not found in common fruits or vegetables. It is strictly an alkaloid derived from the bark of specific trees. There are no dietary sources that provide a therapeutic dose.

Food SourceAmount% DV
Yohimbe Bark (Raw)VariableN/A
Yohimbine HCL (Supplement)StandardizedN/A

Supplementation

Because there are no food sources, supplementation is the only practical way to use Yohimbine.

  • Dosage: A common clinical dosage is 0.2mg per kg of body weight, taken 1 hour before training. Do not exceed this.
  • Timing: Must be taken on an empty stomach (at least 2-3 hours after a meal) to be effective. Food, specifically carbohydrates, triggers an insulin response that blocks Yohimbine from working.
  • Who Should Take It: Healthy adults looking to accelerate fat loss who have hit a plateau, specifically targeting stubborn fat areas.

Top Food Sources

Yohimbe Bark Extract
The only natural source, usually extracted for supplements.
Common Fruits/Vegetables
Yohimbine is NOT found in standard foods.

Frequently Asked Questions

Yohimbine is an alpha-2 antagonist, but insulin (released when you eat) is an alpha-2 agonist. If you eat, insulin wins, and the Yohimbine becomes useless.
No. Yohimbe bark is the raw plant material with varying potency. Yohimbine is the isolated, standardized active compound found in purified supplements. The supplement is safer because the dosage is precise.
When combined with a caloric deficit and fasted cardio, users typically notice effects within 2-4 weeks, specifically regarding stubborn fat reduction.
Yes, but the dosage for libido differs from fat loss. However, because of the cardiovascular risks, it is rarely recommended as a first-line therapy for libido issues.

Safety & Side Effects

Safety & Warnings

Yohimbine is a potent compound with significant risks. It is not for everyone.

  • Cardiovascular Risk: It significantly raises blood pressure and heart rate. Avoid if you have heart conditions, high blood pressure, or anxiety disorders.
  • Drug Interactions: Do not take with antidepressants (MAOIs or SSRIs), stimulants, or other fat burners. This can lead to dangerous spikes in blood pressure (Hypertensive Crisis).
  • Side Effects: Common side effects include rapid heartbeat, dizziness, sweating, nausea, and jitteriness.

Disclaimer: Always consult a healthcare professional before starting Yohimbine, especially if you are currently taking medication.

Scientific References

  • [1]Meyers, A. (1985). 'Yohimbine in the treatment of erectile dysfunction.' *Journal of Urology*.
  • [2]Sincero, S. (2012). 'Mechanisms of Yohimbine Action.' *Journal of Physiology*.
  • [3]Ostojic, S. M. (2006). 'Yohimbine: The effects on body composition and exercise performance.' *Sports Medicine*.