Yohimbine

Bio-Activity Analysis
Effectiveness by Insulin State
SCIENTIFIC DATA VISUALIZATION
Health Benefits & Sources
Why You Need It
- Targeted Fat Loss: It helps mobilize stubborn fat stores, particularly in the lower abdomen and thighs.
- Enhanced Physical Performance: It can improve oxygen uptake and blood flow (vasodilation) during exercise.
- Libido Support: Historically used to support sexual health and drive.
Deep Dive
Yohimbine works by antagonizing alpha-2 adrenergic receptors. These receptors are often found in areas of the body where blood flow is restricted or fat is hard to burn (like the belly). When these receptors are blocked, the body releases norepinephrine, a neurotransmitter that triggers lipolysis (fat breakdown). It effectively fights against the body's natural tendency to store fat in these regions. However, it is a stimulant, meaning it increases heart rate and blood pressure. It is most effective when used in conjunction with exercise and a caloric deficit.
Natural Food Sources
Unlike vitamins or minerals, Yohimbine is not found in common fruits or vegetables. It is strictly an alkaloid derived from the bark of specific trees. There are no dietary sources that provide a therapeutic dose.
| Food Source | Amount | % DV |
|---|---|---|
| Yohimbe Bark (Raw) | Variable | N/A |
| Yohimbine HCL (Supplement) | Standardized | N/A |
Supplementation
Because there are no food sources, supplementation is the only practical way to use Yohimbine.
- Dosage: A common clinical dosage is 0.2mg per kg of body weight, taken 1 hour before training. Do not exceed this.
- Timing: Must be taken on an empty stomach (at least 2-3 hours after a meal) to be effective. Food, specifically carbohydrates, triggers an insulin response that blocks Yohimbine from working.
- Who Should Take It: Healthy adults looking to accelerate fat loss who have hit a plateau, specifically targeting stubborn fat areas.
Top Food Sources
Frequently Asked Questions
Safety & Side Effects
Safety & Warnings
Yohimbine is a potent compound with significant risks. It is not for everyone.
- Cardiovascular Risk: It significantly raises blood pressure and heart rate. Avoid if you have heart conditions, high blood pressure, or anxiety disorders.
- Drug Interactions: Do not take with antidepressants (MAOIs or SSRIs), stimulants, or other fat burners. This can lead to dangerous spikes in blood pressure (Hypertensive Crisis).
- Side Effects: Common side effects include rapid heartbeat, dizziness, sweating, nausea, and jitteriness.
Disclaimer: Always consult a healthcare professional before starting Yohimbine, especially if you are currently taking medication.
Scientific References
- [1]Meyers, A. (1985). 'Yohimbine in the treatment of erectile dysfunction.' *Journal of Urology*.
- [2]Sincero, S. (2012). 'Mechanisms of Yohimbine Action.' *Journal of Physiology*.
- [3]Ostojic, S. M. (2006). 'Yohimbine: The effects on body composition and exercise performance.' *Sports Medicine*.